2o2f
From Proteopedia
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==Solution structure of the anti-apoptotic protein Bcl-2 in complex with an acyl-sulfonamide-based ligand== | ==Solution structure of the anti-apoptotic protein Bcl-2 in complex with an acyl-sulfonamide-based ligand== | ||
| - | <StructureSection load='2o2f' size='340' side='right' caption='[[2o2f | + | <StructureSection load='2o2f' size='340' side='right'caption='[[2o2f]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2o2f]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2o2f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O2F FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LI0:4-(4-BENZYL-4-METHOXYPIPERIDIN-1-YL)-N-[(4-{[1,1-DIMETHYL-2-(PHENYLTHIO)ETHYL]AMINO}-3-NITROPHENYL)SULFONYL]BENZAMIDE'>LI0</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LI0:4-(4-BENZYL-4-METHOXYPIPERIDIN-1-YL)-N-[(4-{[1,1-DIMETHYL-2-(PHENYLTHIO)ETHYL]AMINO}-3-NITROPHENYL)SULFONYL]BENZAMIDE'>LI0</scene></td></tr> | |
| - | <tr | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o2f OCA], [https://pdbe.org/2o2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o2f RCSB], [https://www.ebi.ac.uk/pdbsum/2o2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o2f ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | <table> | + | |
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN] Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions. |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN] Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).<ref>PMID:18570871</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o2/2o2f_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o2/2o2f_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2o2f ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2o2f" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[ | + | *[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Belli | + | [[Category: Large Structures]] |
| - | [[Category: Bruncko | + | [[Category: Belli BA]] |
| - | [[Category: Ding | + | [[Category: Bruncko M]] |
| - | [[Category: Elmore | + | [[Category: Ding H]] |
| - | [[Category: Fesik | + | [[Category: Elmore SW]] |
| - | [[Category: Joseph | + | [[Category: Fesik SW]] |
| - | [[Category: Kunzer | + | [[Category: Joseph MK]] |
| - | [[Category: Martineau | + | [[Category: Kunzer A]] |
| - | [[Category: McClellan | + | [[Category: Martineau D]] |
| - | [[Category: Mitten | + | [[Category: McClellan WJ]] |
| - | [[Category: Ng | + | [[Category: Mitten M]] |
| - | [[Category: Nimmer | + | [[Category: Ng SC]] |
| - | [[Category: Oltersdorf | + | [[Category: Nimmer PM]] |
| - | [[Category: Oost | + | [[Category: Oltersdorf T]] |
| - | [[Category: Park | + | [[Category: Oost TK]] |
| - | [[Category: Petros | + | [[Category: Park CM]] |
| - | [[Category: Rosenberg | + | [[Category: Petros AM]] |
| - | [[Category: Shoemaker | + | [[Category: Rosenberg SH]] |
| - | [[Category: Song | + | [[Category: Shoemaker AR]] |
| - | [[Category: Wang | + | [[Category: Song X]] |
| - | [[Category: Wendt | + | [[Category: Wang X]] |
| - | [[Category: Zhang | + | [[Category: Wendt MD]] |
| - | + | [[Category: Zhang H]] | |
| - | + | ||
| - | + | ||
Current revision
Solution structure of the anti-apoptotic protein Bcl-2 in complex with an acyl-sulfonamide-based ligand
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Categories: Homo sapiens | Large Structures | Belli BA | Bruncko M | Ding H | Elmore SW | Fesik SW | Joseph MK | Kunzer A | Martineau D | McClellan WJ | Mitten M | Ng SC | Nimmer PM | Oltersdorf T | Oost TK | Park CM | Petros AM | Rosenberg SH | Shoemaker AR | Song X | Wang X | Wendt MD | Zhang H
