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2o2m

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==Solution structure of the anti-apoptotic protein Bcl-xL in complex with an acyl-sulfonamide-based ligand==
==Solution structure of the anti-apoptotic protein Bcl-xL in complex with an acyl-sulfonamide-based ligand==
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<StructureSection load='2o2m' size='340' side='right' caption='[[2o2m]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
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<StructureSection load='2o2m' size='340' side='right'caption='[[2o2m]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2o2m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O2M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2O2M FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2o2m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O2M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O2M FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LI0:4-(4-BENZYL-4-METHOXYPIPERIDIN-1-YL)-N-[(4-{[1,1-DIMETHYL-2-(PHENYLTHIO)ETHYL]AMINO}-3-NITROPHENYL)SULFONYL]BENZAMIDE'>LI0</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BCL2L1, BCL2L, BCLX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LI0:4-(4-BENZYL-4-METHOXYPIPERIDIN-1-YL)-N-[(4-{[1,1-DIMETHYL-2-(PHENYLTHIO)ETHYL]AMINO}-3-NITROPHENYL)SULFONYL]BENZAMIDE'>LI0</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o2m OCA], [http://pdbe.org/2o2m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2o2m RCSB], [http://www.ebi.ac.uk/pdbsum/2o2m PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o2m OCA], [https://pdbe.org/2o2m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o2m RCSB], [https://www.ebi.ac.uk/pdbsum/2o2m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o2m ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
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[https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o2/2o2m_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o2/2o2m_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Bcl-2|Bcl-2]]
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*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Belli, B A]]
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[[Category: Large Structures]]
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[[Category: Bruncko, M]]
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[[Category: Belli BA]]
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[[Category: Ding, H]]
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[[Category: Bruncko M]]
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[[Category: Elmore, S W]]
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[[Category: Ding H]]
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[[Category: Fesik, S W]]
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[[Category: Elmore SW]]
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[[Category: Joseph, M K]]
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[[Category: Fesik SW]]
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[[Category: Kunzer, A]]
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[[Category: Joseph MK]]
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[[Category: Martineau, D]]
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[[Category: Kunzer A]]
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[[Category: McClellan, W J]]
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[[Category: Martineau D]]
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[[Category: Mitten, M]]
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[[Category: McClellan WJ]]
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[[Category: Ng, S C]]
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[[Category: Mitten M]]
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[[Category: Nimmer, P M]]
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[[Category: Ng SC]]
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[[Category: Oltersdorf, T]]
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[[Category: Nimmer PM]]
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[[Category: Oost, T K]]
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[[Category: Oltersdorf T]]
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[[Category: Park, C M]]
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[[Category: Oost TK]]
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[[Category: Petros, A M]]
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[[Category: Park CM]]
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[[Category: Rosenberg, S H]]
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[[Category: Petros AM]]
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[[Category: Shoemaker, A R]]
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[[Category: Rosenberg SH]]
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[[Category: Song, X]]
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[[Category: Shoemaker AR]]
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[[Category: Wang, X]]
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[[Category: Song X]]
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[[Category: Wendt, M D]]
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[[Category: Wang X]]
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[[Category: Zhang, H]]
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[[Category: Wendt MD]]
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[[Category: Apoptosis]]
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[[Category: Zhang H]]
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[[Category: Bcl]]
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[[Category: Complex]]
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Current revision

Solution structure of the anti-apoptotic protein Bcl-xL in complex with an acyl-sulfonamide-based ligand

PDB ID 2o2m

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