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2oef

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==Open and Closed Structures of the UDP-Glucose Pyrophosphorylase from Leishmania major==
==Open and Closed Structures of the UDP-Glucose Pyrophosphorylase from Leishmania major==
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<StructureSection load='2oef' size='340' side='right' caption='[[2oef]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='2oef' size='340' side='right'caption='[[2oef]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2oef]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OEF OCA]. <br>
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<table><tr><td colspan='2'>[[2oef]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OEF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OEF FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UGP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5664 Leishmania major])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oef OCA], [https://pdbe.org/2oef PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oef RCSB], [https://www.ebi.ac.uk/pdbsum/2oef PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oef ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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</table>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oef OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oef RCSB], [http://www.ebi.ac.uk/pdbsum/2oef PDBsum]</span></td></tr>
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== Function ==
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<table>
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[https://www.uniprot.org/uniprot/Q4QDU3_LEIMA Q4QDU3_LEIMA]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oe/2oef_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oe/2oef_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2oef ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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Open and closed structures of the UDP-glucose pyrophosphorylase from Leishmania major.,Steiner T, Lamerz AC, Hess P, Breithaupt C, Krapp S, Bourenkov G, Huber R, Gerardy-Schahn R, Jacob U J Biol Chem. 2007 Apr 27;282(17):13003-10. Epub 2007 Feb 15. PMID:17303565<ref>PMID:17303565</ref>
Open and closed structures of the UDP-glucose pyrophosphorylase from Leishmania major.,Steiner T, Lamerz AC, Hess P, Breithaupt C, Krapp S, Bourenkov G, Huber R, Gerardy-Schahn R, Jacob U J Biol Chem. 2007 Apr 27;282(17):13003-10. Epub 2007 Feb 15. PMID:17303565<ref>PMID:17303565</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2oef" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Leishmania major]]
[[Category: Leishmania major]]
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[[Category: UTP--glucose-1-phosphate uridylyltransferase]]
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[[Category: Steiner T]]
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[[Category: Steiner, T.]]
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[[Category: Beta-helix]]
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[[Category: Pyrophosphorylase]]
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[[Category: Rossmann-fold]]
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[[Category: Transferase]]
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Current revision

Open and Closed Structures of the UDP-Glucose Pyrophosphorylase from Leishmania major

PDB ID 2oef

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