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2opj

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==Crystal structure of O-succinylbenzoate synthase==
==Crystal structure of O-succinylbenzoate synthase==
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<StructureSection load='2opj' size='340' side='right' caption='[[2opj]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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<StructureSection load='2opj' size='340' side='right'caption='[[2opj]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2opj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thefy Thefy]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OPJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2opj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermobifida_fusca_YX Thermobifida fusca YX]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OPJ FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tfu_1410 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=269800 THEFY])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2opj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2opj OCA], [http://pdbe.org/2opj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2opj RCSB], [http://www.ebi.ac.uk/pdbsum/2opj PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/2opj TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2opj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2opj OCA], [https://pdbe.org/2opj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2opj RCSB], [https://www.ebi.ac.uk/pdbsum/2opj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2opj ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2opj TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/Q47Q21_THEFY Q47Q21_THEFY]] Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).[HAMAP-Rule:MF_00470][SAAS:SAAS00169585]
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[https://www.uniprot.org/uniprot/MENC_THEFY MENC_THEFY] Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB) (PubMed:24060347, PubMed:24872444). Does not show N-succinylamino acid racemase (NSAR) activity with N-succinyl-L-phenylglycine as substrate (PubMed:24872444).<ref>PMID:24060347</ref> <ref>PMID:24872444</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/op/2opj_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/op/2opj_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2opj ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2opj ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Thefy]]
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[[Category: Large Structures]]
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[[Category: Burley, S K]]
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[[Category: Thermobifida fusca YX]]
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[[Category: Structural genomic]]
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[[Category: Burley SK]]
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[[Category: Sugadev, R]]
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[[Category: Sugadev R]]
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[[Category: Swaminathan, S]]
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[[Category: Swaminathan S]]
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[[Category: Lyase]]
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[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
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[[Category: O-succinylbenzoate]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Tim barrel]]
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Current revision

Crystal structure of O-succinylbenzoate synthase

PDB ID 2opj

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