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2pva
From Proteopedia
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==OXIDIZED PENICILLIN V ACYLASE FROM B. SPHAERICUS== | ==OXIDIZED PENICILLIN V ACYLASE FROM B. SPHAERICUS== | ||
| - | <StructureSection load='2pva' size='340' side='right' caption='[[2pva]], [[Resolution|resolution]] 2.50Å' scene=''> | + | <StructureSection load='2pva' size='340' side='right'caption='[[2pva]], [[Resolution|resolution]] 2.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2pva]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2pva]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lysinibacillus_sphaericus Lysinibacillus sphaericus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PVA FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene>, <scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr> | |
| - | <tr><td class="sblockLbl"><b>[[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pva OCA], [https://pdbe.org/2pva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pva RCSB], [https://www.ebi.ac.uk/pdbsum/2pva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pva ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | == Function == |
| - | <table> | + | [https://www.uniprot.org/uniprot/PAC_LYSSH PAC_LYSSH] The enzyme catalyzes the conversion of penicillin to 6-aminopenicillanate The precursor, furthermore, acts as a self-processing peptidase that cleaves off the propeptide. All peptidase activity is lost on conversion to the mature peptidase. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pv/2pva_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pv/2pva_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pva ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Lysinibacillus sphaericus]] | [[Category: Lysinibacillus sphaericus]] | ||
| - | + | [[Category: Brannigan JA]] | |
| - | [[Category: Brannigan | + | [[Category: Dauter Z]] |
| - | [[Category: Dauter | + | [[Category: Dodson EJ]] |
| - | [[Category: Dodson | + | [[Category: Dodson GG]] |
| - | [[Category: Dodson | + | [[Category: McVey CE]] |
| - | [[Category: McVey | + | [[Category: Pundle AV]] |
| - | [[Category: Pundle | + | [[Category: Rao KN]] |
| - | [[Category: Rao | + | [[Category: SivaRaman H]] |
| - | [[Category: SivaRaman | + | [[Category: Suresh CG]] |
| - | [[Category: Suresh | + | [[Category: Verma CS]] |
| - | [[Category: Verma | + | |
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Current revision
OXIDIZED PENICILLIN V ACYLASE FROM B. SPHAERICUS
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Categories: Large Structures | Lysinibacillus sphaericus | Brannigan JA | Dauter Z | Dodson EJ | Dodson GG | McVey CE | Pundle AV | Rao KN | SivaRaman H | Suresh CG | Verma CS
