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2pva

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Current revision (00:22, 28 December 2023) (edit) (undo)
 
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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2pva]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lysinibacillus_sphaericus Lysinibacillus sphaericus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PVA FirstGlance]. <br>
<table><tr><td colspan='2'>[[2pva]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lysinibacillus_sphaericus Lysinibacillus sphaericus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PVA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene>, <scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3pva|3pva]]</div></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Penicillin_amidase Penicillin amidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.11 3.5.1.11] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pva OCA], [https://pdbe.org/2pva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pva RCSB], [https://www.ebi.ac.uk/pdbsum/2pva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pva ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pva OCA], [https://pdbe.org/2pva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pva RCSB], [https://www.ebi.ac.uk/pdbsum/2pva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pva ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PAC_LYSSH PAC_LYSSH]] The enzyme catalyzes the conversion of penicillin to 6-aminopenicillanate The precursor, furthermore, acts as a self-processing peptidase that cleaves off the propeptide. All peptidase activity is lost on conversion to the mature peptidase.
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[https://www.uniprot.org/uniprot/PAC_LYSSH PAC_LYSSH] The enzyme catalyzes the conversion of penicillin to 6-aminopenicillanate The precursor, furthermore, acts as a self-processing peptidase that cleaves off the propeptide. All peptidase activity is lost on conversion to the mature peptidase.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lysinibacillus sphaericus]]
[[Category: Lysinibacillus sphaericus]]
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[[Category: Penicillin amidase]]
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[[Category: Brannigan JA]]
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[[Category: Brannigan, J A]]
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[[Category: Dauter Z]]
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[[Category: Dauter, Z]]
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[[Category: Dodson EJ]]
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[[Category: Dodson, E J]]
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[[Category: Dodson GG]]
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[[Category: Dodson, G G]]
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[[Category: McVey CE]]
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[[Category: McVey, C E]]
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[[Category: Pundle AV]]
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[[Category: Pundle, A V]]
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[[Category: Rao KN]]
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[[Category: Rao, K N]]
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[[Category: SivaRaman H]]
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[[Category: SivaRaman, H]]
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[[Category: Suresh CG]]
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[[Category: Suresh, C G]]
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[[Category: Verma CS]]
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[[Category: Verma, C S]]
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[[Category: Amidohydrolase]]
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[[Category: Hydrolase]]
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[[Category: Ntn hydrolase]]
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[[Category: Penicillin v acylase]]
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Current revision

OXIDIZED PENICILLIN V ACYLASE FROM B. SPHAERICUS

PDB ID 2pva

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