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2pva

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(New page: 200px<br /><applet load="2pva" size="450" color="white" frame="true" align="right" spinBox="true" caption="2pva, resolution 2.50&Aring;" /> '''OXIDIZED PENICILLIN ...)
Current revision (00:22, 28 December 2023) (edit) (undo)
 
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[[Image:2pva.gif|left|200px]]<br /><applet load="2pva" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2pva, resolution 2.50&Aring;" />
 
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'''OXIDIZED PENICILLIN V ACYLASE FROM B. SPHAERICUS'''<br />
 
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==About this Structure==
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==OXIDIZED PENICILLIN V ACYLASE FROM B. SPHAERICUS==
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2PVA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Lysinibacillus_sphaericus Lysinibacillus sphaericus] with DTD as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Penicillin_amidase Penicillin amidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.11 3.5.1.11] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2PVA OCA].
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<StructureSection load='2pva' size='340' side='right'caption='[[2pva]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2pva]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lysinibacillus_sphaericus Lysinibacillus sphaericus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PVA FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene>, <scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pva OCA], [https://pdbe.org/2pva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pva RCSB], [https://www.ebi.ac.uk/pdbsum/2pva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pva ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PAC_LYSSH PAC_LYSSH] The enzyme catalyzes the conversion of penicillin to 6-aminopenicillanate The precursor, furthermore, acts as a self-processing peptidase that cleaves off the propeptide. All peptidase activity is lost on conversion to the mature peptidase.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pv/2pva_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pva ConSurf].
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<div style="clear:both"></div>
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==Reference==
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==See Also==
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Penicillin V acylase crystal structure reveals new Ntn-hydrolase family members., Suresh CG, Pundle AV, SivaRaman H, Rao KN, Brannigan JA, McVey CE, Verma CS, Dauter Z, Dodson EJ, Dodson GG, Nat Struct Biol. 1999 May;6(5):414-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10331865 10331865]
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*[[Penicillin acylase|Penicillin acylase]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Lysinibacillus sphaericus]]
[[Category: Lysinibacillus sphaericus]]
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[[Category: Penicillin amidase]]
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[[Category: Brannigan JA]]
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[[Category: Single protein]]
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[[Category: Dauter Z]]
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[[Category: Brannigan, J.A.]]
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[[Category: Dodson EJ]]
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[[Category: Dauter, Z.]]
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[[Category: Dodson GG]]
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[[Category: Dodson, E.J.]]
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[[Category: McVey CE]]
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[[Category: Dodson, G.G.]]
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[[Category: Pundle AV]]
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[[Category: McVey, C.E.]]
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[[Category: Rao KN]]
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[[Category: Pundle, A.V.]]
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[[Category: SivaRaman H]]
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[[Category: Rao, K.N.]]
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[[Category: Suresh CG]]
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[[Category: SivaRaman, H.]]
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[[Category: Verma CS]]
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[[Category: Suresh, C.G.]]
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[[Category: Verma, C.S.]]
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[[Category: DTD]]
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[[Category: amidohydrolase]]
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[[Category: ntn hydrolase]]
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[[Category: penicillin v acylase]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 13:41:50 2007''
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Current revision

OXIDIZED PENICILLIN V ACYLASE FROM B. SPHAERICUS

PDB ID 2pva

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