3f3y

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==Crystal structure of human cytosolic sulfotransferase SULT2A1 in complex with PAP and lithocholic acid==
==Crystal structure of human cytosolic sulfotransferase SULT2A1 in complex with PAP and lithocholic acid==
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<StructureSection load='3f3y' size='340' side='right' caption='[[3f3y]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='3f3y' size='340' side='right'caption='[[3f3y]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3f3y]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F3Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F3Y FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3f3y]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F3Y FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4OA:(3BETA,5BETA,14BETA,17ALPHA)-3-HYDROXYCHOLAN-24-OIC+ACID'>4OA</scene>, <scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HST, STD, SULT2A1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4OA:(3BETA,5BETA,14BETA,17ALPHA)-3-HYDROXYCHOLAN-24-OIC+ACID'>4OA</scene>, <scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bile-salt_sulfotransferase Bile-salt sulfotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.2.14 2.8.2.14] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f3y OCA], [https://pdbe.org/3f3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f3y RCSB], [https://www.ebi.ac.uk/pdbsum/3f3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f3y ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f3y OCA], [http://pdbe.org/3f3y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3f3y RCSB], [http://www.ebi.ac.uk/pdbsum/3f3y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3f3y ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ST2A1_HUMAN ST2A1_HUMAN]] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands.
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[https://www.uniprot.org/uniprot/ST2A1_HUMAN ST2A1_HUMAN] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Sulfotransferase|Sulfotransferase]]
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*[[Sulfotransferase 3D structures|Sulfotransferase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bile-salt sulfotransferase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Amaya, M]]
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[[Category: Amaya M]]
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[[Category: Dong, A]]
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[[Category: Dong A]]
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[[Category: Edwards, A M]]
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[[Category: Edwards AM]]
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[[Category: Pan, P W]]
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[[Category: Pan PW]]
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[[Category: Bile acid catabolism]]
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[[Category: Cytoplasm]]
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[[Category: Human cytosolic sulfotransferase]]
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[[Category: Lipid metabolism]]
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[[Category: Lithocholic acid]]
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[[Category: Pap]]
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[[Category: Steroid metabolism]]
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[[Category: Sult2a1]]
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[[Category: Transferase]]
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Current revision

Crystal structure of human cytosolic sulfotransferase SULT2A1 in complex with PAP and lithocholic acid

PDB ID 3f3y

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