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3f89

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==NEMO CoZi domain==
==NEMO CoZi domain==
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<StructureSection load='3f89' size='340' side='right' caption='[[3f89]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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<StructureSection load='3f89' size='340' side='right'caption='[[3f89]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3f89]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F89 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3f89]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F89 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F89 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2zvn|2zvn]], [[2zvo|2zvo]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f89 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f89 RCSB], [http://www.ebi.ac.uk/pdbsum/3f89 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f89 OCA], [https://pdbe.org/3f89 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f89 RCSB], [https://www.ebi.ac.uk/pdbsum/3f89 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f89 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NEMO_MOUSE NEMO_MOUSE]] Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (By similarity).<ref>PMID:9927690</ref>
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[https://www.uniprot.org/uniprot/NEMO_MOUSE NEMO_MOUSE] Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (By similarity).<ref>PMID:9927690</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f8/3f89_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f8/3f89_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3f89 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3f89" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Akutsu, M]]
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[[Category: Akutsu M]]
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[[Category: Bloor, S]]
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[[Category: Bloor S]]
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[[Category: Dikic, I]]
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[[Category: Dikic I]]
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[[Category: Ikeda, F]]
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[[Category: Ikeda F]]
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[[Category: Kato, R]]
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[[Category: Kato R]]
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[[Category: Kawasaki, M]]
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[[Category: Kawasaki M]]
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[[Category: Kensche, T]]
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[[Category: Kensche T]]
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[[Category: Komander, D]]
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[[Category: Komander D]]
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[[Category: Rahighi, S]]
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[[Category: Rahighi S]]
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[[Category: Randow, F]]
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[[Category: Randow F]]
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[[Category: Suzuki, N]]
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[[Category: Suzuki N]]
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[[Category: Uejima, T]]
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[[Category: Uejima T]]
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[[Category: Wakatsuki, S]]
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[[Category: Wakatsuki S]]
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[[Category: Metal-binding]]
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[[Category: Nf-kb signaling]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Ubiquitin binding]]
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[[Category: Zinc-finger]]
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Current revision

NEMO CoZi domain

PDB ID 3f89

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