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3ns1

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==Crystal Structure of Bovine Xanthine Oxidase in Complex with 6-Mercaptopurine==
==Crystal Structure of Bovine Xanthine Oxidase in Complex with 6-Mercaptopurine==
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<StructureSection load='3ns1' size='340' side='right' caption='[[3ns1]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='3ns1' size='340' side='right'caption='[[3ns1]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ns1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NS1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NS1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ns1]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NS1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NS1 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=MOS:DIOXOTHIOMOLYBDENUM(VI)+ION'>MOS</scene>, <scene name='pdbligand=MTE:PHOSPHONIC+ACIDMONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,7,8A,9,10,10A-HEXAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL)ESTER'>MTE</scene>, <scene name='pdbligand=PM6:9H-PURINE-6-THIOL'>PM6</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3eub|3eub]], [[3etr|3etr]], [[3b9j|3b9j]], [[3nrz|3nrz]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=MOS:DIOXOTHIOMOLYBDENUM(VI)+ION'>MOS</scene>, <scene name='pdbligand=MTE:PHOSPHONIC+ACIDMONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,7,8A,9,10,10A-HEXAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL)ESTER'>MTE</scene>, <scene name='pdbligand=PM6:9H-PURINE-6-THIOL'>PM6</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ns1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ns1 OCA], [http://pdbe.org/3ns1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ns1 RCSB], [http://www.ebi.ac.uk/pdbsum/3ns1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ns1 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ns1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ns1 OCA], [https://pdbe.org/3ns1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ns1 RCSB], [https://www.ebi.ac.uk/pdbsum/3ns1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ns1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/XDH_BOVIN XDH_BOVIN]] Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species.
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[https://www.uniprot.org/uniprot/XDH_BOVIN XDH_BOVIN] Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Xanthine dehydrogenase|Xanthine dehydrogenase]]
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*[[Xanthine dehydrogenase 3D structures|Xanthine dehydrogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Cao, H]]
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[[Category: Large Structures]]
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[[Category: Hille, R]]
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[[Category: Cao H]]
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[[Category: Pauff, J M]]
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[[Category: Hille R]]
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[[Category: Hydroxylase]]
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[[Category: Pauff JM]]
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[[Category: Hypoxanthine]]
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[[Category: Oxidoreductase]]
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[[Category: Substrate orientation]]
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[[Category: Xanthine oxidase]]
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Current revision

Crystal Structure of Bovine Xanthine Oxidase in Complex with 6-Mercaptopurine

PDB ID 3ns1

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