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4oyf

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==Crystal structure of GLTPH R397A IN Sodium-bound state==
==Crystal structure of GLTPH R397A IN Sodium-bound state==
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<StructureSection load='4oyf' size='340' side='right' caption='[[4oyf]], [[Resolution|resolution]] 3.41&Aring;' scene=''>
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<StructureSection load='4oyf' size='340' side='right'caption='[[4oyf]], [[Resolution|resolution]] 3.41&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4oyf]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OYF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OYF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4oyf]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OYF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OYF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.41&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4oye|4oye]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oyf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oyf RCSB], [http://www.ebi.ac.uk/pdbsum/4oyf PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oyf OCA], [https://pdbe.org/4oyf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oyf RCSB], [https://www.ebi.ac.uk/pdbsum/4oyf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oyf ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GLT_PYRHO GLT_PYRHO] Sodium-dependent, high-affinity amino acid transporter that mediates aspartate uptake (PubMed:17435767, PubMed:19380583, PubMed:17230192, Ref.11). Has only very low glutamate transport activity (PubMed:19380583, PubMed:17230192). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions, resulting in electrogenic transport (PubMed:17435767, PubMed:19380583, Ref.11). Na(+) binding enhances the affinity for aspartate (PubMed:19380583, Ref.11). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:17435767). In contrast to mammalian homologs, transport does not depend on pH or K(+) ions (PubMed:19380583).<ref>PMID:17230192</ref> <ref>PMID:17435767</ref> <ref>PMID:19380583</ref> [PDB:4P19]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4oyf" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Symporter 3D structures|Symporter 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Boudker, O]]
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[[Category: Large Structures]]
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[[Category: Oh, S]]
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[[Category: Pyrococcus horikoshii]]
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[[Category: Serio, R]]
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[[Category: Boudker O]]
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[[Category: Verdon, G]]
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[[Category: Oh S]]
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[[Category: Alpha helical]]
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[[Category: Serio R]]
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[[Category: Helical hairpin]]
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[[Category: Verdon G]]
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[[Category: Membrane protein]]
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[[Category: Transport protein]]
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[[Category: Unwound region]]
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Current revision

Crystal structure of GLTPH R397A IN Sodium-bound state

PDB ID 4oyf

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