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4p0q

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==Crystal structure of Human Mus81-Eme1 in complex with 5'-flap DNA==
==Crystal structure of Human Mus81-Eme1 in complex with 5'-flap DNA==
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<StructureSection load='4p0q' size='340' side='right' caption='[[4p0q]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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<StructureSection load='4p0q' size='340' side='right'caption='[[4p0q]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4p0q]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P0Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P0Q FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4p0q]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P0Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P0Q FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4p0p|4p0p]], [[4p0r|4p0r]], [[4p0s|4p0s]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.851&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p0q OCA], [http://pdbe.org/4p0q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p0q RCSB], [http://www.ebi.ac.uk/pdbsum/4p0q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p0q ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p0q OCA], [https://pdbe.org/4p0q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p0q RCSB], [https://www.ebi.ac.uk/pdbsum/4p0q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p0q ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MUS81_HUMAN MUS81_HUMAN]] Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.<ref>PMID:11741546</ref> <ref>PMID:12374758</ref> <ref>PMID:12686547</ref> <ref>PMID:12721304</ref> <ref>PMID:14617801</ref> <ref>PMID:15805243</ref> <ref>PMID:17289582</ref> <ref>PMID:19595721</ref> <ref>PMID:19596235</ref> [[http://www.uniprot.org/uniprot/EME1_HUMAN EME1_HUMAN]] Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.<ref>PMID:12686547</ref> <ref>PMID:12721304</ref> <ref>PMID:14617801</ref> <ref>PMID:17289582</ref>
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[https://www.uniprot.org/uniprot/MUS81_HUMAN MUS81_HUMAN] Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.<ref>PMID:11741546</ref> <ref>PMID:12374758</ref> <ref>PMID:12686547</ref> <ref>PMID:12721304</ref> <ref>PMID:14617801</ref> <ref>PMID:15805243</ref> <ref>PMID:17289582</ref> <ref>PMID:19595721</ref> <ref>PMID:19596235</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Endonuclease|Endonuclease]]
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*[[Endonuclease 3D structures|Endonuclease 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Baek, K]]
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[[Category: Homo sapiens]]
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[[Category: Cho, Y]]
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[[Category: Large Structures]]
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[[Category: Gwon, G H]]
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[[Category: Synthetic construct]]
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[[Category: Hydrolase-dna complex]]
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[[Category: Baek K]]
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[[Category: Resolvase]]
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[[Category: Cho Y]]
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[[Category: Gwon GH]]

Current revision

Crystal structure of Human Mus81-Eme1 in complex with 5'-flap DNA

PDB ID 4p0q

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