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4p5a
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==Crystal structure of a UMP/dUMP methylase PolB from Streptomyces cacaoi bound with 5-Br UMP== | ==Crystal structure of a UMP/dUMP methylase PolB from Streptomyces cacaoi bound with 5-Br UMP== | ||
| - | <StructureSection load='4p5a' size='340' side='right' caption='[[4p5a]], [[Resolution|resolution]] 1.76Å' scene=''> | + | <StructureSection load='4p5a' size='340' side='right'caption='[[4p5a]], [[Resolution|resolution]] 1.76Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4p5a]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P5A OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4p5a]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_asoensis Streptomyces asoensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P5A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P5A FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.76Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5BU:5-BROMO-URIDINE-5-MONOPHOSPHATE'>5BU</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p5a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p5a OCA], [https://pdbe.org/4p5a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p5a RCSB], [https://www.ebi.ac.uk/pdbsum/4p5a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p5a ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/C1IC19_9ACTN C1IC19_9ACTN] Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.[HAMAP-Rule:MF_01408] |
| + | |||
| + | ==See Also== | ||
| + | *[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Streptomyces asoensis]] |
| - | [[Category: | + | [[Category: Chen W]] |
| - | [[Category: | + | [[Category: Deng Z]] |
| - | + | [[Category: Li J]] | |
| - | [[Category: | + | [[Category: Li Y]] |
| - | [[Category: | + | [[Category: Xia Z]] |
| - | [[Category: | + | [[Category: Zhou J]] |
| - | [[Category: | + | |
| - | + | ||
Current revision
Crystal structure of a UMP/dUMP methylase PolB from Streptomyces cacaoi bound with 5-Br UMP
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Categories: Large Structures | Streptomyces asoensis | Chen W | Deng Z | Li J | Li Y | Xia Z | Zhou J
