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4pfa
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==Crystal structure of M. tuberculosis in complex with BTO - covalent adduct== | ==Crystal structure of M. tuberculosis in complex with BTO - covalent adduct== | ||
| - | <StructureSection load='4pfa' size='340' side='right' caption='[[4pfa]], [[Resolution|resolution]] 2.56Å' scene=''> | + | <StructureSection load='4pfa' size='340' side='right'caption='[[4pfa]], [[Resolution|resolution]] 2.56Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4pfa]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PFA OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4pfa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PFA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PFA FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=N77:7-(HYDROXYAMINO)-N-(PYRIDIN-3-YLMETHYL)-5-(TRIFLUOROMETHYL)-1,3-BENZOTHIAZOLE-2-CARBOXAMIDE+3-OXIDE'>N77</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.56Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=N77:7-(HYDROXYAMINO)-N-(PYRIDIN-3-YLMETHYL)-5-(TRIFLUOROMETHYL)-1,3-BENZOTHIAZOLE-2-CARBOXAMIDE+3-OXIDE'>N77</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pfa OCA], [https://pdbe.org/4pfa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pfa RCSB], [https://www.ebi.ac.uk/pdbsum/4pfa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pfa ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/DPRE1_MYCTU DPRE1_MYCTU] Involved in the epimerization of decaprenylphosphoryl ribose (DPR) to decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Probably catalyzes the oxidation at C-2 of decaprenylphosphoryl ribose (DPR) to yield decaprenylphosphoryl 2-keto-ribose (DPX).<ref>PMID:16291675</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Mycobacterium tuberculosis H37Rv]] |
| - | [[Category: | + | [[Category: Cole S]] |
| - | [[Category: | + | [[Category: Neres J]] |
| - | [[Category: | + | [[Category: Panda M]] |
| - | + | ||
| - | + | ||
Current revision
Crystal structure of M. tuberculosis in complex with BTO - covalent adduct
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