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4pir

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<StructureSection load='4pir' size='340' side='right'caption='[[4pir]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<StructureSection load='4pir' size='340' side='right'caption='[[4pir]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4pir]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PIR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PIR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4pir]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Lama_glama Lama glama] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PIR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PIR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Htr3a, 5ht3, Htr3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pir OCA], [http://pdbe.org/4pir PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pir RCSB], [http://www.ebi.ac.uk/pdbsum/4pir PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pir ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pir OCA], [https://pdbe.org/4pir PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pir RCSB], [https://www.ebi.ac.uk/pdbsum/4pir PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pir ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/5HT3A_MOUSE 5HT3A_MOUSE]] This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.
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[https://www.uniprot.org/uniprot/5HT3A_MOUSE 5HT3A_MOUSE] This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[5-ht3a receptor|5-ht3a receptor]]
 
*[[5-hydroxytryptamine receptor 3D structures|5-hydroxytryptamine receptor 3D structures]]
*[[5-hydroxytryptamine receptor 3D structures|5-hydroxytryptamine receptor 3D structures]]
== References ==
== References ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Camelus glama]]
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[[Category: Lama glama]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Deluz, C]]
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[[Category: Deluz C]]
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[[Category: Desmyter, A]]
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[[Category: Desmyter A]]
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[[Category: Graff, A]]
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[[Category: Graff A]]
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[[Category: Grasso, L]]
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[[Category: Grasso L]]
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[[Category: Hassaine, G]]
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[[Category: Hassaine G]]
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[[Category: Hovius, R]]
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[[Category: Hovius R]]
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[[Category: Li, X D]]
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[[Category: Li X-D]]
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[[Category: Moreau, C]]
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[[Category: Moreau C]]
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[[Category: Nury, H]]
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[[Category: Nury H]]
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[[Category: Poitevin, F]]
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[[Category: Poitevin F]]
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[[Category: Stahlberg, H]]
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[[Category: Stahlberg H]]
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[[Category: Tol, M B]]
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[[Category: Tol MB]]
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[[Category: Tomizaki, T]]
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[[Category: Tomizaki T]]
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[[Category: Vogel, H]]
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[[Category: Vogel H]]
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[[Category: Wyss, R]]
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[[Category: Wyss R]]
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[[Category: Ion channel]]
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[[Category: Membrane transport]]
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[[Category: Transport protein]]
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Current revision

X-ray structure of the mouse serotonin 5-HT3 receptor

PDB ID 4pir

Drag the structure with the mouse to rotate

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