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4pkm

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'''Unreleased structure'''
 
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The entry 4pkm is ON HOLD until Paper Publication
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==Crystal Structure of Bacillus thuringiensis Cry51Aa1 Protoxin at 1.65 Angstroms Resolution==
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<StructureSection load='4pkm' size='340' side='right'caption='[[4pkm]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4pkm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_thuringiensis_F14-1 Bacillus thuringiensis F14-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PKM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PKM FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pkm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pkm OCA], [https://pdbe.org/4pkm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pkm RCSB], [https://www.ebi.ac.uk/pdbsum/4pkm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pkm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A7IZR5_BACTU A7IZR5_BACTU]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structures of several Bacillus thuringiensis (Bt) insecticidal crystal proteins have been determined by crystallographic methods and a close relationship has been explicated between specific toxicities and conserved three-dimensional architectures. In this study, as a representative of the coleopteran- and hemipteran-specific Cry51A group, the complete structure of Cry51Aa1 protoxin has been determined by X-ray crystallography at 1.65 A resolution. This is the first report of a coleopteran-active Bt insecticidal toxin with high structural similarity to the aerolysin-type beta-pore forming toxins (beta-PFTs). Moreover, study of featured residues and structural elements reveal their possible roles in receptor binding and pore formation events. This study provides new insights into the action of aerolysin-type beta-PFTs from a structural perspective, and could be useful for the control of coleopteran and hemipteran insect pests in agricultures.
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Authors: Xu, C., Chinte, U., Chen, L., Yao, Q., Zhou, D., Meng, Y., Li, L., Rose, J., Bi, L.J., Yu, Z., Sun, M., Wang, B.C.
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Crystal structure of Cry51Aa1: A potential novel insecticidal aerolysin-type beta-pore-forming toxin from Bacillus thuringiensis.,Xu C, Chinte U, Chen L, Yao Q, Meng Y, Zhou D, Bi LJ, Rose J, Adang MJ, Wang BC, Yu Z, Sun M Biochem Biophys Res Commun. 2015 May 7. pii: S0006-291X(15)00758-5. doi:, 10.1016/j.bbrc.2015.04.068. PMID:25957471<ref>PMID:25957471</ref>
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Description: Crystal Structure of Bacillus thuringiensis Cry51Aa1 Protoxin at 1.65 Angstroms Resolution
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4pkm" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Bacillus thuringiensis F14-1]]
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[[Category: Large Structures]]
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[[Category: Bi LJ]]
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[[Category: Chen L]]
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[[Category: Chinte U]]
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[[Category: Li L]]
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[[Category: Meng Y]]
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[[Category: Rose J]]
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[[Category: Sun M]]
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[[Category: Wang BC]]
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[[Category: Xu C]]
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[[Category: Yao Q]]
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[[Category: Yu Z]]
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[[Category: Zhou D]]

Current revision

Crystal Structure of Bacillus thuringiensis Cry51Aa1 Protoxin at 1.65 Angstroms Resolution

PDB ID 4pkm

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