4tt2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (00:47, 28 December 2023) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Crystal structure of ATAD2A bromodomain complexed with H4(1-20)K5Ac peptide==
==Crystal structure of ATAD2A bromodomain complexed with H4(1-20)K5Ac peptide==
-
<StructureSection load='4tt2' size='340' side='right' caption='[[4tt2]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+
<StructureSection load='4tt2' size='340' side='right'caption='[[4tt2]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4tt2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TT2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TT2 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4tt2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TT2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TT2 FirstGlance]. <br>
-
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4tt4|4tt4]], [[4tt6|4tt6]], [[4tte|4tte]], [[4tu4|4tu4]], [[4tu6|4tu6]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tt2 OCA], [https://pdbe.org/4tt2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tt2 RCSB], [https://www.ebi.ac.uk/pdbsum/4tt2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tt2 ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tt2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tt2 RCSB], [http://www.ebi.ac.uk/pdbsum/4tt2 PDBsum]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN]] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>
+
[https://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 18: Line 18:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 4tt2" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[ATPase family AAA domain-containing protein|ATPase family AAA domain-containing protein]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Adenosinetriphosphatase]]
+
[[Category: Homo sapiens]]
-
[[Category: Andersen, J]]
+
[[Category: Large Structures]]
-
[[Category: Bardenhagen, J]]
+
[[Category: Andersen J]]
-
[[Category: Cardozo, M]]
+
[[Category: Bardenhagen J]]
-
[[Category: Do, M Geck]]
+
[[Category: Cardozo M]]
-
[[Category: Jones, P]]
+
[[Category: Geck Do M]]
-
[[Category: Ladbury, J]]
+
[[Category: Jones P]]
-
[[Category: Lee, G]]
+
[[Category: Ladbury J]]
-
[[Category: Leo, E]]
+
[[Category: Lee G]]
-
[[Category: Leonard, P]]
+
[[Category: Leo E]]
-
[[Category: Palmer, W]]
+
[[Category: Leonard P]]
-
[[Category: Petrocchi, A]]
+
[[Category: Palmer W]]
-
[[Category: Poncet-Montange, G]]
+
[[Category: Petrocchi A]]
-
[[Category: Shi, X]]
+
[[Category: Poncet-Montange G]]
-
[[Category: Zhan, Y]]
+
[[Category: Shi X]]
-
[[Category: Bromodomain-acetylated histone complex]]
+
[[Category: Zhan Y]]
-
[[Category: Gene regulation]]
+

Current revision

Crystal structure of ATAD2A bromodomain complexed with H4(1-20)K5Ac peptide

PDB ID 4tt2

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4tt2"
Personal tools