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4txp

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==Crystal structure of LIP5 N-terminal domain==
==Crystal structure of LIP5 N-terminal domain==
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<StructureSection load='4txp' size='340' side='right' caption='[[4txp]], [[Resolution|resolution]] 3.01&Aring;' scene=''>
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<StructureSection load='4txp' size='340' side='right'caption='[[4txp]], [[Resolution|resolution]] 3.01&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4txp]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TXP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TXP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4txp]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TXP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TXP FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4txq|4txq]], [[4txr|4txr]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.01&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4txp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4txp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4txp RCSB], [http://www.ebi.ac.uk/pdbsum/4txp PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4txp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4txp OCA], [https://pdbe.org/4txp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4txp RCSB], [https://www.ebi.ac.uk/pdbsum/4txp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4txp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/VTA1_HUMAN VTA1_HUMAN]] Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). Involved in HIV-1 budding.<ref>PMID:15644320</ref>
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[https://www.uniprot.org/uniprot/VTA1_HUMAN VTA1_HUMAN] Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). Involved in HIV-1 budding.<ref>PMID:15644320</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4txp" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Vacuolar protein sorting-associated protein 3D structures|Vacuolar protein sorting-associated protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Vild, C J]]
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[[Category: Homo sapiens]]
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[[Category: Xu, Z]]
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[[Category: Large Structures]]
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[[Category: Escrt]]
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[[Category: Vild CJ]]
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[[Category: Mit]]
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[[Category: Xu Z]]
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[[Category: Mit domain]]
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[[Category: Protein transport]]
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Current revision

Crystal structure of LIP5 N-terminal domain

PDB ID 4txp

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