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4u41
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==MAP4K4 Bound to inhibitor compound 1== | |
| - | + | <StructureSection load='4u41' size='340' side='right'caption='[[4u41]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4u41]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U41 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U41 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3C8:6-[(3S)-3-(4-METHYL-1H-PYRAZOL-3-YL)PIPERIDIN-1-YL]PYRIDO[3,2-D]PYRIMIDIN-4-AMINE'>3C8</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u41 OCA], [https://pdbe.org/4u41 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u41 RCSB], [https://www.ebi.ac.uk/pdbsum/4u41 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u41 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/M4K4_HUMAN M4K4_HUMAN] Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.<ref>PMID:9890973</ref> <ref>PMID:21690388</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Coons M]] | ||
| + | [[Category: Harris SF]] | ||
| + | [[Category: Wu P]] | ||
Current revision
MAP4K4 Bound to inhibitor compound 1
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