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4u42
From Proteopedia
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<StructureSection load='4u42' size='340' side='right'caption='[[4u42]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='4u42' size='340' side='right'caption='[[4u42]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4u42]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4u42]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U42 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U42 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3C8:6-[(3S)-3-(4-METHYL-1H-PYRAZOL-3-YL)PIPERIDIN-1-YL]PYRIDO[3,2-D]PYRIMIDIN-4-AMINE'>3C8</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.504Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3C8:6-[(3S)-3-(4-METHYL-1H-PYRAZOL-3-YL)PIPERIDIN-1-YL]PYRIDO[3,2-D]PYRIMIDIN-4-AMINE'>3C8</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u42 OCA], [https://pdbe.org/4u42 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u42 RCSB], [https://www.ebi.ac.uk/pdbsum/4u42 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u42 ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/M4K4_HUMAN M4K4_HUMAN] Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.<ref>PMID:9890973</ref> <ref>PMID:21690388</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | + | [[Category: Coons M]] | |
| - | [[Category: Coons | + | [[Category: Harris SF]] |
| - | [[Category: Harris | + | [[Category: Wu P]] |
| - | [[Category: Wu | + | |
| - | + | ||
| - | + | ||
Current revision
MAP4K4 T181E Mutant Bound to inhibitor compound 1
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