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4wa4

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==The crystal structure of neuraminidase from a H3N8 influenza virus isolated from New England harbor seals in complex with oseltamivir carboxylate==
==The crystal structure of neuraminidase from a H3N8 influenza virus isolated from New England harbor seals in complex with oseltamivir carboxylate==
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<StructureSection load='4wa4' size='340' side='right' caption='[[4wa4]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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<StructureSection load='4wa4' size='340' side='right'caption='[[4wa4]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4wa4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WA4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WA4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4wa4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/harbor_seal/Massachusetts/1/2011(H3N8)) Influenza A virus (A/harbor seal/Massachusetts/1/2011(H3N8))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WA4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WA4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=G39:(3R,4R,5S)-4-(ACETYLAMINO)-5-AMINO-3-(PENTAN-3-YLOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC+ACID'>G39</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wa1|4wa1]], [[4wa2|4wa2]], [[4wa3|4wa3]], [[4wa5|4wa5]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=G39:(3R,4R,5S)-4-(ACETYLAMINO)-5-AMINO-3-(PENTAN-3-YLOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC+ACID'>G39</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wa4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wa4 OCA], [http://pdbe.org/4wa4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wa4 RCSB], [http://www.ebi.ac.uk/pdbsum/4wa4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wa4 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wa4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wa4 OCA], [https://pdbe.org/4wa4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wa4 RCSB], [https://www.ebi.ac.uk/pdbsum/4wa4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wa4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/I6NW33_9INFA I6NW33_9INFA]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.[RuleBase:RU361252]
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[https://www.uniprot.org/uniprot/I6NW33_9INFA I6NW33_9INFA] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.[RuleBase:RU361252]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4wa4" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4wa4" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Neuraminidase 3D structures|Neuraminidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Gubareva, L V]]
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[[Category: Large Structures]]
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[[Category: Stevens, J]]
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[[Category: Gubareva LV]]
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[[Category: Villanueva, J M]]
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[[Category: Stevens J]]
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[[Category: Yang, H]]
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[[Category: Villanueva JM]]
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[[Category: Influenza virus]]
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[[Category: Yang H]]
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[[Category: Neuraminidase]]
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[[Category: Seal]]
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[[Category: Viral protein-inhibitor complex]]
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Current revision

The crystal structure of neuraminidase from a H3N8 influenza virus isolated from New England harbor seals in complex with oseltamivir carboxylate

PDB ID 4wa4

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