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4whw
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Direct photocapture of bromodomains using tropolone chemical probes== | |
| + | <StructureSection load='4whw' size='340' side='right'caption='[[4whw]], [[Resolution|resolution]] 1.34Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4whw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WHW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WHW FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.345Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3OT:2-METHOXY-4-{1-[2-(MORPHOLIN-4-YL)ETHYL]-2-(2-PHENYLETHYL)-1H-BENZIMIDAZOL-5-YL}CYCLOHEPTA-2,4,6-TRIEN-1-ONE'>3OT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4whw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4whw OCA], [https://pdbe.org/4whw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4whw RCSB], [https://www.ebi.ac.uk/pdbsum/4whw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4whw ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Basak A]] | ||
| + | [[Category: Bonin PD]] | ||
| + | [[Category: Denny RA]] | ||
| + | [[Category: Flick AC]] | ||
| + | [[Category: Geoghegan KF]] | ||
| + | [[Category: Hett EC]] | ||
| + | [[Category: Jones LH]] | ||
| + | [[Category: Liu S]] | ||
| + | [[Category: Piatnitski Chekler EL]] | ||
| + | [[Category: Pletcher MT]] | ||
| + | [[Category: Robinson RP]] | ||
| + | [[Category: Sahasrabudhe P]] | ||
| + | [[Category: Salter S]] | ||
| + | [[Category: Stock IA]] | ||
Current revision
Direct photocapture of bromodomains using tropolone chemical probes
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Categories: Homo sapiens | Large Structures | Basak A | Bonin PD | Denny RA | Flick AC | Geoghegan KF | Hett EC | Jones LH | Liu S | Piatnitski Chekler EL | Pletcher MT | Robinson RP | Sahasrabudhe P | Salter S | Stock IA
