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4wk8

From Proteopedia

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Current revision

FOXP3 forms a domain-swapped dimer to bridge DNA

Structural highlights

4wk8 is a 4 chain structure with sequence from Homo sapiens and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 3.4006Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

FOXP3_HUMAN Immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome. The disease is caused by mutations affecting the gene represented in this entry.

Function

FOXP3_HUMAN Probable transcription factor. Plays a critical role in the control of immune response.

Publication Abstract from PubMed

FOXP3 is a lineage-specific transcription factor that is required for regulatory T cell development and function. In this study, we determined the crystal structure of the FOXP3 forkhead domain bound to DNA. The structure reveals that FOXP3 can form a stable domain-swapped dimer to bridge DNA in the absence of cofactors, suggesting that FOXP3 may play a role in long-range gene interactions. To test this hypothesis, we used circular chromosome conformation capture coupled with high throughput sequencing (4C-seq) to analyze FOXP3-dependent genomic contacts around a known FOXP3-bound locus, Ptpn22. Our studies reveal that FOXP3 induces significant changes in the chromatin contacts between the Ptpn22 locus and other Foxp3-regulated genes, reflecting a mechanism by which FOXP3 reorganizes the genome architecture to coordinate the expression of its target genes. Our results suggest that FOXP3 mediates long-range chromatin interactions as part of its mechanisms to regulate specific gene expression in regulatory T cells.

DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions.,Chen Y, Chen C, Zhang Z, Liu CC, Johnson ME, Espinoza CA, Edsall LE, Ren B, Zhou XJ, Grant SF, Wells AD, Chen L Nucleic Acids Res. 2015 Jan 7. pii: gku1373. PMID:25567984^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Chen Y, Chen C, Zhang Z, Liu CC, Johnson ME, Espinoza CA, Edsall LE, Ren B, Zhou XJ, Grant SF, Wells AD, Chen L. DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions. Nucleic Acids Res. 2015 Jan 7. pii: gku1373. PMID:25567984 doi:http://dx.doi.org/10.1093/nar/gku1373

1 Structural highlights
2 Disease
3 Function
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4wk8"

Categories: Homo sapiens | Large Structures | Synthetic construct | Chen L | Chen Y

@@ Line 1: / Line 1: @@
 ==FOXP3 forms a domain-swapped dimer to bridge DNA==
-<StructureSection load='4wk8' size='340' side='right' caption='[[4wk8]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
+<StructureSection load='4wk8' size='340' side='right'caption='[[4wk8]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4wk8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WK8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WK8 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4wk8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WK8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WK8 FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FOXP3, IPEX, JM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4006&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wk8 OCA], [http://pdbe.org/4wk8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wk8 RCSB], [http://www.ebi.ac.uk/pdbsum/4wk8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wk8 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wk8 OCA], [https://pdbe.org/4wk8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wk8 RCSB], [https://www.ebi.ac.uk/pdbsum/4wk8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wk8 ProSAT]</span></td></tr>
 </table>
 == Disease ==
-[[http://www.uniprot.org/uniprot/FOXP3_HUMAN FOXP3_HUMAN]] Immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome. The disease is caused by mutations affecting the gene represented in this entry.
+[https://www.uniprot.org/uniprot/FOXP3_HUMAN FOXP3_HUMAN] Immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome. The disease is caused by mutations affecting the gene represented in this entry.
 == Function ==
-[[http://www.uniprot.org/uniprot/FOXP3_HUMAN FOXP3_HUMAN]] Probable transcription factor. Plays a critical role in the control of immune response.
+[https://www.uniprot.org/uniprot/FOXP3_HUMAN FOXP3_HUMAN] Probable transcription factor. Plays a critical role in the control of immune response.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 20: / Line 20: @@
 </div>
 <div class="pdbe-citations 4wk8" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[FOX 3D structures|FOX 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Chen, L]]
+[[Category: Large Structures]]
-[[Category: Chen, Y]]
+[[Category: Synthetic construct]]
-[[Category: Dna bridging]]
+[[Category: Chen L]]
-[[Category: Foxp3]]
+[[Category: Chen Y]]
-[[Category: Regulatory t cell]]
-[[Category: Transcription regulation]]
-[[Category: Transcription-dna complex]]

4wk8

From Proteopedia

Current revision

FOXP3 forms a domain-swapped dimer to bridge DNA

Structural highlights

Disease

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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