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4x4p

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==Crystal structure of the A.fulgidus CCA-adding enzyme in complex with a G70A arginyl-tRNA minihelix ending in CCAC==
==Crystal structure of the A.fulgidus CCA-adding enzyme in complex with a G70A arginyl-tRNA minihelix ending in CCAC==
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<StructureSection load='4x4p' size='340' side='right' caption='[[4x4p]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<StructureSection load='4x4p' size='340' side='right'caption='[[4x4p]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4x4p]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Arcfu Arcfu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X4P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X4P FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4x4p]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus_DSM_4304 Archaeoglobus fulgidus DSM 4304] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X4P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X4P FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4x4n|4x4n]], [[4x4o|4x4o]], [[4x4q|4x4q]], [[4x4r|4x4r]], [[4x4s|4x4s]], [[4x4t|4x4t]], [[4x4u|4x4u]], [[4x4v|4x4v]], [[4x4w|4x4w]], [[4x4x|4x4x]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cca, AF_2156 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224325 ARCFU])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x4p OCA], [https://pdbe.org/4x4p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x4p RCSB], [https://www.ebi.ac.uk/pdbsum/4x4p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x4p ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/CCA_tRNA_nucleotidyltransferase CCA tRNA nucleotidyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.72 2.7.7.72] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x4p OCA], [http://pdbe.org/4x4p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x4p RCSB], [http://www.ebi.ac.uk/pdbsum/4x4p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4x4p ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CCA_ARCFU CCA_ARCFU]] Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.<ref>PMID:14592988</ref>
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[https://www.uniprot.org/uniprot/CCA_ARCFU CCA_ARCFU] Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.<ref>PMID:14592988</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[TRNA|TRNA]]
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*[[CCA-adding enzyme 3D structures|CCA-adding enzyme 3D structures]]
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*[[Transfer RNA (tRNA)|Transfer RNA (tRNA)]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arcfu]]
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[[Category: Archaeoglobus fulgidus DSM 4304]]
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[[Category: CCA tRNA nucleotidyltransferase]]
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[[Category: Homo sapiens]]
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[[Category: Joshua-Tor, L]]
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[[Category: Large Structures]]
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[[Category: Kuhn, C D]]
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[[Category: Joshua-Tor L]]
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[[Category: Cca-adding enzyme]]
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[[Category: Kuhn C-D]]
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[[Category: Ncrna]]
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[[Category: Non-coding rna]]
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[[Category: Nucleotidyltransferase]]
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[[Category: Protein-rna complex]]
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[[Category: Rna binding protein]]
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[[Category: Trna]]
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Current revision

Crystal structure of the A.fulgidus CCA-adding enzyme in complex with a G70A arginyl-tRNA minihelix ending in CCAC

PDB ID 4x4p

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