5h3o

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==Structure of a eukaryotic cyclic nucleotide-gated channel==
==Structure of a eukaryotic cyclic nucleotide-gated channel==
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<StructureSection load='5h3o' size='340' side='right' caption='[[5h3o]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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<SX load='5h3o' size='340' side='right' viewer='molstar' caption='[[5h3o]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5h3o]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H3O FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5h3o]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H3O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5H3O FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PCG:CYCLIC+GUANOSINE+MONOPHOSPHATE'>PCG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h3o OCA], [http://pdbe.org/5h3o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h3o RCSB], [http://www.ebi.ac.uk/pdbsum/5h3o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h3o ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PCG:CYCLIC+GUANOSINE+MONOPHOSPHATE'>PCG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5h3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h3o OCA], [https://pdbe.org/5h3o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5h3o RCSB], [https://www.ebi.ac.uk/pdbsum/5h3o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5h3o ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CNG_CAEEL CNG_CAEEL]] Required for normal thermosensation and chemosensation sensory behavior (PubMed:8893027). Required, downstream of receptor-type guanylate cyclase gcy-9, for CO2-mediated responses in BAG neurons (PubMed:21173231). Required, downstream of receptor-type guanylate cyclase gcy-14, for alkaline pH-mediated responses in ASE-left (ASEL) neurons (PubMed:23664973). Involved in the development of ASJ sensory neuron axon during late larval stages and in the maintenance of normal axon morphology in the adult. Regulates dauer formation (PubMed:9486798). In ASI and ASJ sensory neurons, controls behavioral response to P.aeruginosa by up-regulating the transcription of daf-7, a member of the TGF-beta family (PubMed:25303524). In AWB and AWC sensory neurons, mediates the recognition of food oders which subsequently allows for the detection of preferred food sources (PubMed:25009271).<ref>PMID:21173231</ref> <ref>PMID:23664973</ref> <ref>PMID:25009271</ref> <ref>PMID:25303524</ref> <ref>PMID:8893027</ref> <ref>PMID:9486798</ref>
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[https://www.uniprot.org/uniprot/CNG_CAEEL CNG_CAEEL] Required for normal thermosensation and chemosensation sensory behavior (PubMed:8893027). Required, downstream of receptor-type guanylate cyclase gcy-9, for CO2-mediated responses in BAG neurons (PubMed:21173231). Required, downstream of receptor-type guanylate cyclase gcy-14, for alkaline pH-mediated responses in ASE-left (ASEL) neurons (PubMed:23664973). Involved in the development of ASJ sensory neuron axon during late larval stages and in the maintenance of normal axon morphology in the adult. Regulates dauer formation (PubMed:9486798). In ASI and ASJ sensory neurons, controls behavioral response to P.aeruginosa by up-regulating the transcription of daf-7, a member of the TGF-beta family (PubMed:25303524). In AWB and AWC sensory neurons, mediates the recognition of food oders which subsequently allows for the detection of preferred food sources (PubMed:25009271).<ref>PMID:21173231</ref> <ref>PMID:23664973</ref> <ref>PMID:25009271</ref> <ref>PMID:25303524</ref> <ref>PMID:8893027</ref> <ref>PMID:9486798</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Cyclic-nucleotide-gated channels are essential for vision and olfaction. They belong to the voltage-gated ion channel superfamily but their activities are controlled by intracellular cyclic nucleotides instead of transmembrane voltage. Here we report a 3.5-A-resolution single-particle electron cryo-microscopy structure of a cyclic-nucleotide-gated channel from Caenorhabditis elegans in the cyclic guanosine monophosphate (cGMP)-bound open state. The channel has an unusual voltage-sensor-like domain, accounting for its deficient voltage dependence. A carboxy-terminal linker connecting S6 and the cyclic-nucleotide-binding domain interacts directly with both the voltage-sensor-like domain and the pore domain, forming a gating ring that couples conformational changes triggered by cyclic nucleotide binding to the gate. The selectivity filter is lined by the carboxylate side chains of a functionally important glutamate and three rings of backbone carbonyls. This structure provides a new framework for understanding mechanisms of ion permeation, gating and channelopathy of cyclic-nucleotide-gated channels and cyclic nucleotide modulation of related channels.
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Structure of a eukaryotic cyclic-nucleotide-gated channel.,Li M, Zhou X, Wang S, Michailidis I, Gong Y, Su D, Li H, Li X, Yang J Nature. 2017 Feb 2;542(7639):60-65. doi: 10.1038/nature20819. Epub 2017 Jan 18. PMID:28099415<ref>PMID:28099415</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5h3o" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Ion channels 3D structures|Ion channels 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Gong, Y]]
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[[Category: Caenorhabditis elegans]]
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[[Category: Li, H]]
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[[Category: Large Structures]]
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[[Category: Li, M]]
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[[Category: Gong Y]]
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[[Category: Li, X]]
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[[Category: Li H]]
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[[Category: Michailidis, I]]
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[[Category: Li M]]
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[[Category: Su, D]]
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[[Category: Li X]]
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[[Category: Wang, S]]
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[[Category: Michailidis I]]
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[[Category: Yang, J]]
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[[Category: Su D]]
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[[Category: Zhou, X]]
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[[Category: Wang S]]
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[[Category: Channel]]
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[[Category: Yang J]]
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[[Category: Cng]]
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[[Category: Zhou X]]
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[[Category: Open state]]
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[[Category: Tax-4]]
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[[Category: Transport protein]]
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Current revision

Structure of a eukaryotic cyclic nucleotide-gated channel

5h3o, resolution 3.50Å

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