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5pa0

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==humanized rat COMT in complex with 3-hydroxy-1-methyl-5-phenylpyridin-2-one==
==humanized rat COMT in complex with 3-hydroxy-1-methyl-5-phenylpyridin-2-one==
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<StructureSection load='5pa0' size='340' side='right' caption='[[5pa0]], [[Resolution|resolution]] 1.26&Aring;' scene=''>
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<StructureSection load='5pa0' size='340' side='right'caption='[[5pa0]], [[Resolution|resolution]] 1.26&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5pa0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PA0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5PA0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5pa0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PA0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5PA0 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7JR:1-methyl-3-oxidanyl-5-phenyl-pyridin-2-one'>7JR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CXS:3-CYCLOHEXYL-1-PROPYLSULFONIC+ACID'>CXS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.26&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SME:METHIONINE+SULFOXIDE'>SME</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7JR:1-methyl-3-oxidanyl-5-phenyl-pyridin-2-one'>7JR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CXS:3-CYCLOHEXYL-1-PROPYLSULFONIC+ACID'>CXS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SME:METHIONINE+SULFOXIDE'>SME</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catechol_O-methyltransferase Catechol O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.6 2.1.1.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5pa0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5pa0 OCA], [https://pdbe.org/5pa0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5pa0 RCSB], [https://www.ebi.ac.uk/pdbsum/5pa0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5pa0 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5pa0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5pa0 OCA], [http://pdbe.org/5pa0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5pa0 RCSB], [http://www.ebi.ac.uk/pdbsum/5pa0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5pa0 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/COMT_RAT COMT_RAT]] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
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[https://www.uniprot.org/uniprot/COMT_RAT COMT_RAT] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
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==See Also==
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*[[Catechol O-methyltransferase 3D structures|Catechol O-methyltransferase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Catechol O-methyltransferase]]
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[[Category: Large Structures]]
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[[Category: Ehler, A]]
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[[Category: Rattus norvegicus]]
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[[Category: Lerner, C]]
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[[Category: Ehler A]]
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[[Category: Rudolph, M G]]
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[[Category: Lerner C]]
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[[Category: Methyltransferase]]
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[[Category: Rudolph MG]]
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[[Category: Neurotransmitter degradation]]
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[[Category: Transferase]]
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Current revision

humanized rat COMT in complex with 3-hydroxy-1-methyl-5-phenylpyridin-2-one

PDB ID 5pa0

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