5pb1

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(New page: '''Unreleased structure''' The entry 5pb1 is ON HOLD Authors: Stihle, M., Mayweg, A., Roever, S., Rudolph, M.G. Description: Crystal Structure of Factor VIIa in complex with benzenecar...)
Current revision (01:38, 28 December 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 5pb1 is ON HOLD
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==Crystal Structure of Factor VIIa in complex with benzenecarboximidamide==
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<StructureSection load='5pb1' size='340' side='right'caption='[[5pb1]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5pb1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PB1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5PB1 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MHO:S-OXYMETHIONINE'>MHO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5pb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5pb1 OCA], [https://pdbe.org/5pb1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5pb1 RCSB], [https://www.ebi.ac.uk/pdbsum/5pb1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5pb1 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/FA7_HUMAN FA7_HUMAN] Defects in F7 are the cause of factor VII deficiency (FA7D) [MIM:[https://omim.org/entry/227500 227500]. A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels.<ref>PMID:8043443</ref> <ref>PMID:2070047</ref> <ref>PMID:1634227</ref> <ref>PMID:8364544</ref> <ref>PMID:8204879</ref> <ref>PMID:7981691</ref> <ref>PMID:7974346</ref> <ref>PMID:8652821</ref> <ref>PMID:8844208</ref> <ref>PMID:8940045</ref> <ref>PMID:8883260</ref> <ref>PMID:9414278</ref> <ref>PMID:9576180</ref> <ref>PMID:9452082</ref> <ref>PMID:11091194</ref> <ref>PMID:11129332</ref> <ref>PMID:10862079</ref> <ref>PMID:12472587</ref> <ref>PMID:14717781</ref> <ref>PMID:19751712</ref> <ref>PMID:18976247</ref> <ref>PMID:19432927</ref> <ref>PMID:21206266</ref> <ref>PMID:21372693</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/FA7_HUMAN FA7_HUMAN] Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
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Authors: Stihle, M., Mayweg, A., Roever, S., Rudolph, M.G.
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==See Also==
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*[[Factor VIIa 3D structures|Factor VIIa 3D structures]]
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Description: Crystal Structure of Factor VIIa in complex with benzenecarboximidamide
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Roever, S]]
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__TOC__
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[[Category: Stihle, M]]
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</StructureSection>
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[[Category: Rudolph, M.G]]
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[[Category: Homo sapiens]]
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[[Category: Mayweg, A]]
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[[Category: Large Structures]]
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[[Category: Mayweg A]]
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[[Category: Roever S]]
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[[Category: Rudolph MG]]
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[[Category: Stihle M]]

Current revision

Crystal Structure of Factor VIIa in complex with benzenecarboximidamide

PDB ID 5pb1

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