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Transcriptional activator 3D structures

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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
-
*Gcn4 transcriptional activator see [[Gcn4]]
+
*Gcn4 TA See [[Gcn4]]
-
*Gcn5 transcriptional activator
+
*Gcn5 TA
**[[1e6i]] – yTA brododomain + histone H4 peptide - yeast<br />
**[[1e6i]] – yTA brododomain + histone H4 peptide - yeast<br />
**[[1ygh]] – yTA histone acetyltransferase domain <br />
**[[1ygh]] – yTA histone acetyltransferase domain <br />
-
*C-Myb transcriptional activator; domains - DBD repeat 1 38-89; DBD repeat 2 90-141; DBD repeat 3 142-193; transcriptional activation (TAD) 291-315
+
*C-Myb TA; domains – DBD ; DBD repeat 1 38-89; repeat 2 90-141; repeat 3 142-193; transcription activation 291-315
-
**[[1mse]], [[1msf]] – mTA DBD repeat 1,2 + DNA - mouse - NMR<br />
+
**[[1mse]], [[1msf]] – mTA DBD 90-193 + DNA – NMR - mouse<br />
**[[1mbe]], [[1mbf]] – mTA DBD repeat 1 + DNA - NMR<br />
**[[1mbe]], [[1mbf]] – mTA DBD repeat 1 + DNA - NMR<br />
**[[1mbg]], [[1mbh]] – mTA DBD repeat 2 + DNA - NMR<br />
**[[1mbg]], [[1mbh]] – mTA DBD repeat 2 + DNA - NMR<br />
**[[1mbj]], [[1mbk]] – mTA DBD repeat 3 + DNA - NMR<br />
**[[1mbj]], [[1mbk]] – mTA DBD repeat 3 + DNA - NMR<br />
-
**[[1h88]] – mTA DBD repeat 1,2,3 + DNA + CCAAT/enhancer binding protein β<br />
+
**[[1h88]] – mTA DBD + DNA + CCAAT/enhancer binding protein β<br />
-
**[[1h89]] – mTA DBD repeat 1,2,3 + DNA + CAAT/enhancer binding protein β<br />
+
**[[1h89]] – mTA DBD + DNA + CAAT/enhancer binding protein β<br />
**[[1guu]] – mTA DBD repeat 1 <br />
**[[1guu]] – mTA DBD repeat 1 <br />
**[[1gv2]] – mTA DBD repeat 2,3 <br />
**[[1gv2]] – mTA DBD repeat 2,3 <br />
Line 24: Line 24:
**[[1gvd]] – mTA DBD repeat 2 (mutant) <br />
**[[1gvd]] – mTA DBD repeat 2 (mutant) <br />
**[[1idy]], [[1idz]] – mTA DBD repeat 3 (mutant) - NMR<br />
**[[1idy]], [[1idz]] – mTA DBD repeat 3 (mutant) - NMR<br />
-
**[[1sb0]], [[2agh]] – mTA TAD + CREB-binding protein - NMR<br />
+
**[[1sb0]], [[2agh]] – mTA transcription activation domain + CREB-binding protein - NMR<br />
-
**[[2agh]] – mTA TAD + CREB-binding protein + HRX - NMR<br />
+
**[[6dmx]], [[6dnq]] – mTA transcription activation domain + CREB-binding protein p3ptide + Bzip factor <br />
-
**[[6dmx]], [[6dnq]] – mTA TAD + CREB-binding protein + BZIP factor <br />
+
-
*Psp operon transcriptional activator
+
*Psp operon TA
-
**[[2bjw]] – EcTA AAA domain – ''Escherichia coli''<br />
+
**[[2bjw]] – EcTA AAA domain –'' Escherichia coli''<br />
-
**[[2bjv]], [[2c9c]], [[4qnm]] – EcTA AAA domain (mutant)<br />
+
-
**[[2c96]] – EcTA AAA domain + ATP<br />
+
**[[4qnr]] – EcTA AAA domain (mutant) + ATP<br />
**[[4qnr]] – EcTA AAA domain (mutant) + ATP<br />
**[[4qos]] – EcTA AAA domain (mutant) + ADP<br />
**[[4qos]] – EcTA AAA domain (mutant) + ADP<br />
Line 38: Line 35:
**[[2c99]] – EcTA AAA domain + AMPPNP<br />
**[[2c99]] – EcTA AAA domain + AMPPNP<br />
**[[2vii]] – EcTA AAA domain + AMP + Mg<br />
**[[2vii]] – EcTA AAA domain + AMP + Mg<br />
-
**[[5nss]] – EcTA AAA domain + RNAP subunits αββ'ω + DNA - Cryo EM<br />
+
**[[5nss]] – EcTA in RNA polymerase complex – Cryo EM<br />
-
*TenA transcriptional activator
+
*TenA TA
**[[1tyh]], [[1yaf]] – BsTA – ''Bacillus subtilis''<br />
**[[1tyh]], [[1yaf]] – BsTA – ''Bacillus subtilis''<br />
Line 49: Line 46:
**[[1udd]] – TA – ''Pyrococcus horikishii''<br />
**[[1udd]] – TA – ''Pyrococcus horikishii''<br />
-
*LasR transcriptional activator or transcriptional regulator LasR
+
*LasR TA or transcriptional regulator LasR
**[[6mww]] – PaTA – ''Pseudomonas aeruginosa''<br />
**[[6mww]] – PaTA – ''Pseudomonas aeruginosa''<br />
-
**[[2uv0]] – PaTA LBD residues 1-173<br />
+
**[[2uv0]] – PaTA LBD residues 1-173 <br />
**[[3ix3]], [[6mvn]], [[6mvm]] – PaTA LBD + oxo-dodecanoyl-homoserine lactone<br />
**[[3ix3]], [[6mvn]], [[6mvm]] – PaTA LBD + oxo-dodecanoyl-homoserine lactone<br />
-
**[[3ix4]], [[3ix8]], [[3jpu]], [[6d6a]], [[6d6b]], [[6d6c]], [[6d6d]], [[6d6l]], [[6d6m]], [[6d6n]], [[6d6o]], [[6d6p]] – PaTA LBD + benzoate derivative<br />
+
**[[3ix4]], [[3ix8]], [[3jpu]], [[6d6a]], [[6d6b]], [[6d6c]], [[6d6d]], **[[6d6p]], [[6d6l]], [[6d6m]], [[6d6o]], [[6d6n]] – PaTA LBD + benzoate derivative<br />
**[[6mwl]] – PaTA + oxothiolan derivative<br />
**[[6mwl]] – PaTA + oxothiolan derivative<br />
**[[6mwh]] – PaTA + acetamide derivative<br />
**[[6mwh]] – PaTA + acetamide derivative<br />
**[[4ng2]] – PaTA LBD + protein<br />
**[[4ng2]] – PaTA LBD + protein<br />
**[[6mwz]] – PaTA (mutant) + peptide<br />
**[[6mwz]] – PaTA (mutant) + peptide<br />
 +
**[[6v7w]], [[6v7x]] – PaTA + Aqs1<br />
-
*CadC transcriptional activator; domains - DBD 1-107; periplasmic 188-512
+
*CadC TA
-
**[[3ly7]], [[3lya]] – EcTA periplasmic domain <br />
+
**[[3ly7]], [[3lya]] – EcTA periplasmic domain 188-512<br />
**[[3ly8]], [[3ly9]] – EcTA periplasmic domain (mutant)<br />
**[[3ly8]], [[3ly9]] – EcTA periplasmic domain (mutant)<br />
-
**[[5ju7]] – EcTA DBD domain <br />
+
**[[5ju7]] – EcTA DBD 2-107<br />
-
*CynR transcriptional activator
+
*Mal-Rpel TA
-
 
+
-
**[[2hxr]] – EcTA LBD <br />
+
-
**[[3hfu]] – EcTA LBD + N3<br />
+
-
 
+
-
*Mal-Rpel transcriptional activator
+
**[[2v51]], [[2v52]] – mTA residues 16-41 + actin <br />
**[[2v51]], [[2v52]] – mTA residues 16-41 + actin <br />
**[[2yje]], [[2yjf]] – mTA Rpel domain + actin <br />
**[[2yje]], [[2yjf]] – mTA Rpel domain + actin <br />
-
*Brg1 transcriptional activator
+
*Brg1 TA
-
 
+
-
**[[5ea1]] – hTA bromodomain - human<br />
+
-
**[[3uvd]] – hTA bromodomain + pyrrolidone derivative <br />
+
-
**[[5dkd]] – hTA bromodomain + pyridine derivative <br />
+
-
 
+
-
*VP30 transcriptional activator
+
 +
**[[5ea1]] – hTA bromodomain 1418-1536 - human<br />
 +
**[[3uvd]] – hTA bromodomain - NMR<br />
 +
**[[2grc]], [[3uvd]], [[5dkd]], [[6zs2]] – hTA bromodomain + inhibitor<br />
 +
**[[6hr2]] – hTA bromodomain + ElonginB + ElonginC + pVHL<br />
**[[2i8b]] – TA C terminal – Zaire ebolavirus<br />
**[[2i8b]] – TA C terminal – Zaire ebolavirus<br />
**[[3v7o]] – TA C terminal – Reston ebolavirus<br />
**[[3v7o]] – TA C terminal – Reston ebolavirus<br />
-
*TraR transcriptional activator
+
*Flagelar TA
-
 
+
-
**[[1v4r]] – AtTA N-terminal - ''Streptomyces'' - NMR <br />
+
-
**[[1l3l]] – AtTA + pheromone + DNA – ''Agrobacterium tumefaciens'' <br />
+
-
**[[1h0m]] – AtTA + auto-inducer + DNA <br />
+
-
**[[5w1s]] – EcTA + RNAP subunits αββ'ω + PROD + DNA <br />
+
-
 
+
-
*Flagelar transcriptional activator
+
**[[1g8e]] – EcTA FlhD<br />
**[[1g8e]] – EcTA FlhD<br />
-
**[[2avu]] – EcTA FlhC+FlhD<br />
+
**[[2avu]] – EcTA FlhC+FLHD<br />
**[[5hxg]] – StTA FlhD + STM1697 <br />
**[[5hxg]] – StTA FlhD + STM1697 <br />
-
*TipA transcriptional activator
+
*Tipa TA
**[[1ny9]] – SlTA antibiotic binding domain – ''Streptomyces lividans'' - NMR<br />
**[[1ny9]] – SlTA antibiotic binding domain – ''Streptomyces lividans'' - NMR<br />
**[[2mbz]], [[2mc0]] - SlTA antibiotic binding domain + thiopeptide - NMR<br />
**[[2mbz]], [[2mc0]] - SlTA antibiotic binding domain + thiopeptide - NMR<br />
-
**[[2vz4]] – SlTA DBD + DNA<br />
+
**[[1r8d]] – BsTA <br />
-
*MtaN transcriptional activator
+
*Rfah TA
-
 
+
-
**[[1r8d]], [[1jbg]] – BsTA N-terminal <br />
+
-
**[[4p54]] – TA (mutant) - ''Helicobacter pylori'' <br />
+
-
 
+
-
*RfaH transcriptional activator
+
**[[2oug]] – EcTA <br />
**[[2oug]] – EcTA <br />
**[[2lcl]] – EcTA C terminal - NMR<br />
**[[2lcl]] – EcTA C terminal - NMR<br />
-
**[[5ond]] – EcTA (mutant) + DNA <br />
+
**[[5ond]] – EcTA + DNA <br />
-
*SoxR transcriptional activator
+
*SoxR TA or redox-sensitive transcriptional activator
**[[2zhh]] – EcTA <br />
**[[2zhh]] – EcTA <br />
**[[2zhg]] – EcTA + DNA<br />
**[[2zhg]] – EcTA + DNA<br />
 +
**[[6tf4]] – VcTA C terminal - ''Vibrio cholera'' - NMR<br />
-
*AmpR transcriptional activator
+
*GlxR TA
-
 
+
-
**[[3kos]] – CfTA effector binding domain – ''Citrobacter freundii''<br />
+
-
**[[3kot]] – CfTA effector binding domain (mutant)<br />
+
-
**[[4wkm]] – CfTA effector binding domain + peptide<br />
+
-
**[[5mmh]] – PaTA effector binding domain<br />
+
-
 
+
-
*GlxR transcriptional activator
+
-
**[[4byy]] – CgTA – ''Corynebacterium glutamicum'' <br />
+
**[[3r6s]] – CgTA +cAMP – ''Corynebacterium glutamicum'' <br />
-
**[[3r6s]], [[4cyd]] – CgTA + cAMP <br />
+
**[[4byy]] – CgTA <br />
-
*OxyR transcriptional activator
+
*OxyR TA or hydrogen peroxide-inducible genes activator
**[[3t22]], [[3ho7]], [[3uki]] – TA regulatory domain – ''Porphyromonas gingivalis'' <br />
**[[3t22]], [[3ho7]], [[3uki]] – TA regulatory domain – ''Porphyromonas gingivalis'' <br />
-
**[[3jvt]] – TA – ''Neiserria meningitidis'' <br />
+
**[[7l4s]] – TA regulatory domain – ''Shewnella oneidensis''<br />
-
**[[4x6g]] – PaTA (mutant) <br />
+
**[[4y0m]] – PaTA regulatory domain <br />
-
**[[4y0m]] – PaTA regulatory domain <br />
+
**[[4x6g]], [[4xws]] – PaTA regulatory domain (mutant)<br />
-
**[[4xws]] – PaTA regulatory domain (mutant) <br />
+
**[[1i69]], [[1i6a]] – EcTA regulatory domain (mutant)<br />
-
**[[5x0v]] – VvTA-2 regulatory domain - ''Vibrio vulnificus'' <br />
+
**[[6g1d]] – CgTA regulatory domain (mutant)<br />
-
**[[5x0q]], [[5b70]], [[5b7d]], [[5b7h]] – VvTA-2 regulatory domain (mutant)<br />
+
**[[6g1b]], [[6g4r]] – CgTA regulatory domain + H2O2<br />
 +
**[[5x0v]] – VvTA - ''Vibrio vulnificus''<br />
 +
**[[5b70]], [[5b7d]], [[5b7h]], [[5x0q]] – VvTA (mutant) <br />
 +
**[[3jv9]] – NmTA – ''Neisseria meningitidis'' <br />
-
*PlcR transcriptional activator
+
*PlcR TA
**[[4fsc]] – BtTA - ''Bacillus thuringiensis'' <br />
**[[4fsc]] – BtTA - ''Bacillus thuringiensis'' <br />
-
**[[2qfc]] – BtTA + PAPR peptide <br />
+
**[[2qfc]] – BtTA + PapR peptide <br />
-
**[[3u3w]] – BtTA + DNA + PAPR peptide <br />
+
**[[3u3w]] – BtTA + DNA + PapR peptide <br />
-
*VirB transcriptional activator
+
*VirB TA or virulence regulon transcriptional activator VirB
**[[3vwb]], [[3w2a]], [[3w3c]] – TA core domain + DNA – ''Shigella flexneri''<br />
**[[3vwb]], [[3w2a]], [[3w3c]] – TA core domain + DNA – ''Shigella flexneri''<br />
-
*MafA transcriptional activator
+
*MafA TA
**[[4eot]] – hTA DBD<br />
**[[4eot]] – hTA DBD<br />
-
*CysB transcriptional activator
+
*CysB TA or Cys regulon transcriptional activator CysB
**[[4gwo]], [[4gxa]], [[4lon]], [[4lp2]] – StTA C terminal – ''Salmonella typhimurium''<br />
**[[4gwo]], [[4gxa]], [[4lon]], [[4lp2]] – StTA C terminal – ''Salmonella typhimurium''<br />
Line 166: Line 142:
**[[5z4y]], [[5z4z]] – PaTA NTD domain <br />
**[[5z4y]], [[5z4z]] – PaTA NTD domain <br />
-
*HlyU transcriptional activator
+
*HlyU TA
-
**[[4k2e]], [[4ooi]] – VcTA - ''Vibrio cholerae''<br />
+
**[[4k2e]], [[4ooi]] – VcTA <br />
-
**[[3jth]] – VvTA - ''Vibrio vulnificus'' <br />
+
**[[3jth]] – VvTA <br />
-
**[[5znx]] – VvTA + inhibitor<br />
+
**[[5znx]] – VvTA + inhibitor <br />
*ToxR TA
*ToxR TA
**[[6uue]], [[6utc]] – VvTA <br />
**[[6uue]], [[6utc]] – VvTA <br />
 +
**[[7nmb]], [[7nn6]] – VcTA - NMR<br />
 +
**[[8b4b]], [[8b4c]], [[8b4d]], [[8b4e]] – VcTA + DNA<br />
 +
**[[8alo]] – VcTA + ToxS<br />
*LysR TA
*LysR TA
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**[[5x0n]] – VvTA (mutant)<br />
**[[5x0n]] – VvTA (mutant)<br />
**[[3t1b]], [[3szp]] – VcTA <br />
**[[3t1b]], [[3szp]] – VcTA <br />
-
**[[6yz3]] – PaTA <br />
+
**[[6tpr]], [[6z07]], [[6z17]], [[6z5k]], [[6yz3]], [[7o2t]], [[7o2u]] – PaTA + antagonist<br />
 +
**[[6yiz]], [[7nbw]] – PaTA + agonist<br />
**[[5z7h]] – SaTA <br />
**[[5z7h]] – SaTA <br />
**[[4pzj]] – TA – ''Eggerthella lenta''<br />
**[[4pzj]] – TA – ''Eggerthella lenta''<br />
-
**[[3hhf]] – NmTA – ''Neisseria meningitidis'' <br />
+
**[[3hhf]], [[3hhg]], [[4ab5]] – NmTA <br />
**[[3fzj]] – TA – ''Comamonas testosteroni''<br />
**[[3fzj]] – TA – ''Comamonas testosteroni''<br />
 +
**[[1ixc]], [[1iz1]] – CnTA – ''Cupriavidus necator''<br />
 +
**[[5xxp]], [[7d98]] – CnTA + DNA<br />
 +
**[[1uth]], [[2y7r]], [[5ae4]] – TA – ''Burkholderia cepacia''<br />
 +
**[[7trv]], [[7trw]] – TA LBD – ''Yersinia pestis''<br />
 +
**[[7erp]], [[7erq]] – CsTA regulatory domain – ''Cronobacter sakazakii''<br />
 +
**[[7fdf]] – CsTA regulatory domain (mutant) <br />
-
*Aft2 transcriptional activator
+
*Aft2 TA
**[[4lmg]] – yTA + DNA<br />
**[[4lmg]] – yTA + DNA<br />
-
*Cmpr transcriptional activator
+
*Mga TA
-
 
+
-
**[[5z49]] – TA effector-binding domain + ribulose bisphosphate – ''Synechococcus elongatus''<br />
+
-
 
+
-
*Mga transcriptional activator
+
**[[5way]] – SpTA – ''Streptococcus pneumoniae''<br />
**[[5way]] – SpTA – ''Streptococcus pneumoniae''<br />
-
*RhaR transcriptional activator
+
*Spt7 TA
-
 
+
-
**[[5u9e]], [[5u93]] – TA regulatory domain – ''Bacteria latreille''<br />
+
-
 
+
-
*Spt7 transcriptional activator
+
**[[6t9k]], [[6t9i]] – yTA in SAGA – Cryo EM<br />
**[[6t9k]], [[6t9i]] – yTA in SAGA – Cryo EM<br />
-
*Quorum-sensing TA
+
*Quorum-sensing TA or TraR
**[[5l07]] – YeTA – ''Yersinia enterocolitica''<br />
**[[5l07]] – YeTA – ''Yersinia enterocolitica''<br />
**[[5l09]] – YeTA + THF derivative<br />
**[[5l09]] – YeTA + THF derivative<br />
 +
**[[1l3l]] – AtTA + pheromone + DNA – ''Agrobacterium tumefaciens'' <br />
 +
**[[1h0m]] – AtTA + auto-inducer + DNA <br />
*MexT TA
*MexT TA
Line 218: Line 198:
*ComR TA
*ComR TA
-
**[[5juf]] – TA – ''Streptococcus thermophilus''<br />
+
**[[5juf]], [[6qer]] – StTA – ''Streptococcus thermophilus''<br />
-
 
+
**[[5jub]] – StTA + DNA<br />
-
*GabR TA
+
**[[5fd4]] – TA – ''Streptococcus suis''<br />
-
 
+
**[[7n10]], [[7n1n]] – SmTA DBD + Prx – ''Streptococcus mutans''<br />
-
**[[5t4k]], [[5t4j]], [[5t4l]] – BsTA EBO domain + pyridine derivative<br />
+
**[[6hu8]] – SvTA – ''Streptococcus vestibularis''<br />
 +
**[[6hua]] – SvTA + peptide<br />
*FasR TA
*FasR TA
Line 228: Line 209:
**[[6o6p]] – MtTA + DNA – ''Mycobacterium tuberculosis''<br />
**[[6o6p]] – MtTA + DNA – ''Mycobacterium tuberculosis''<br />
**[[6o6o]] – MtTA + myristic acid<br />
**[[6o6o]] – MtTA + myristic acid<br />
-
 
+
**[[6o6n]] – MtTA + arachinoyl-CoA<br />
-
*PrpR TA
+
-
 
+
-
**[[6d2s]], [[6cyj]], [[6cz6]], [[6cyy]] – MtTA <br />
+
-
 
+
-
 
+
-
*LrpC TA
+
-
 
+
-
**[[2cfx]] – BsTA <br />
+
*ModE TA
*ModE TA
**[[1o7l]], [[1h9s]] – EcTA + Mo <br />
**[[1o7l]], [[1h9s]] – EcTA + Mo <br />
-
**[[1b9m]], [[1b9n]] , [[1h9r]]– EcTA + Ni <br />
+
**[[1b9m]], [[1b9n]], [[1h9r]] – EcTA + Ni <br />
-
 
+
-
*RutR TA
+
-
 
+
-
**[[4x1e]] – EcTA <br />
+
-
**[[4xk4]], [[4jyk]] – EcTA + uracil derivative<br />
+
*TetR family TA
*TetR family TA
Line 255: Line 223:
**[[3cwr]] – TA – ''Rhodspirillum rubrum''<br />
**[[3cwr]] – TA – ''Rhodspirillum rubrum''<br />
**[[1z0x]] – EfTA – ''Enterococcus faecalis''<br />
**[[1z0x]] – EfTA – ''Enterococcus faecalis''<br />
-
**[[3vuq]] – TtTA – ''Thermus thermophilus''<br />
 
**[[3c2b]] – AfTA – ''Agrobacterium fabrum''<br />
**[[3c2b]] – AfTA – ''Agrobacterium fabrum''<br />
**[[2o7t]] – CgTA <br />
**[[2o7t]] – CgTA <br />
**[[2g7s]] – AtTA <br />
**[[2g7s]] – AtTA <br />
-
**[[5d19]] – MtTA <br />
 
**[[3gzi]] – TA – ''Shewanella loihica''<br />
**[[3gzi]] – TA – ''Shewanella loihica''<br />
-
**[[3dcf]] – TA – ''Thermobifida fusca''<br />
+
**[[2qib]], [[2zcx]], [[7ky1]] – ScTA – ''Streptomyces coelicolor''<br />
-
**[[2qib]], [[2zcx]], [[6srm]] – TA – ''Streptomyces coelicolor''<br />
+
**[[2hyt]] – TA – ''Pectobacterium atrosepticum''<br />
**[[2hyt]] – TA – ''Pectobacterium atrosepticum''<br />
**[[3cdl]] – PsTA – ''Pseudomonas syringae''<br />
**[[3cdl]] – PsTA – ''Pseudomonas syringae''<br />
-
**[[3kkc]] – TA – ''Streptococcus agalactiae''<br />
+
**[[3kkc]] – SaTA – ''Streptococcus agalactiae''<br />
-
**[[3mvp]] – TA – ''Streptococcus mutans''<br />
+
**[[3nnr]] – TA – ''Marinobacter aquaeolei''<br />
**[[3nnr]] – TA – ''Marinobacter aquaeolei''<br />
**[[3on4]] – TA – ''Legionella pneumophila''<br />
**[[3on4]] – TA – ''Legionella pneumophila''<br />
-
**[[2eh3]] – TA – ''Aquifex aeolicus''<br />
 
**[[3f1b]] – RjTA – ''Rhodococcus jostii''<br />
**[[3f1b]] – RjTA – ''Rhodococcus jostii''<br />
-
**[[3eup]] – TA – ''Cytophaga hutchinsonii''<br />
+
**[[3eup]] – TA – ''Cytophaga hutchinsoni''i<br />
**[[3egq]] – TA – ''Archaeoglobus fulgidus''<br />
**[[3egq]] – TA – ''Archaeoglobus fulgidus''<br />
-
**[[4hku]] – TA – ''Listeria monocytogenes''<br />
+
**[[4hku]] – LmTA – Listeria monocytogenes<br />
**[[3nrg]], [[3qbm]] – TA – ''Chlotoflexus aurantiacus''<br />
**[[3nrg]], [[3qbm]] – TA – ''Chlotoflexus aurantiacus''<br />
-
**[[6g87]] – BdTA – ''Bradyrhizobium diazoefficiens''<br />
 
-
**[[6g8h]] – BdTA + naringenin <br />
 
-
**[[6g8g]] – BdTA + genistein <br />
 
**[[6nsr]] – PaTA (mutant) + DNA<br />
**[[6nsr]] – PaTA (mutant) + DNA<br />
**[[4jkz]] – MsTA – ''Mycobacterium smegmatis''<br />
**[[4jkz]] – MsTA – ''Mycobacterium smegmatis''<br />
**[[6el2]] – SacTA – ''Sulfolobus acidocaldarius''<br />
**[[6el2]] – SacTA – ''Sulfolobus acidocaldarius''<br />
**[[6en8]] – SacTA + DNA<br />
**[[6en8]] – SacTA + DNA<br />
 +
 +
*TetR/AcrR family TA
 +
 +
**[[2rae]] – RjTA <br />
 +
**[[3lhq]] – StTA <br />
 +
**[[3b81]] – CpTA – ''Clostridium acetobutylicum''<br />
 +
**[[3dcf]] – TA – ''Thermobifida fusca''<br />
 +
**[[3mvp]] – SmTA <br />
 +
**[[5d18]], [[5d19]], [[6a4l]], [[6a4w]] – MtTA <br />
 +
**[[2eh3]] – TA – ''Aquifex aeolicus''<br />
 +
**[[3vuq]] – TtTA – ''Thermus thermophilus''<br />
 +
**[[7eqe]] – SgTA – ''Streptococcus griseus''<br />
 +
**[[7eqf]] – SgTA + ligand<br />
 +
**[[5gp9]], [[5gpa]] – BhTA – ''Bacillus halodurans''<br />
 +
**[[5gpc]] – BhTA + DNA <br />
 +
**[[6g87]] – BdTA – ''Bradyrhizobium diazoefficiens''<br />
 +
**[[6g8h]] – BdTA + naringenin <br />
 +
**[[6g8g]] – BdTA + genistein <br />
*GntR family TA
*GntR family TA
Line 287: Line 265:
**[[3l5z]] – BcTA <br />
**[[3l5z]] – BcTA <br />
**[[3ddv]] – EfTA <br />
**[[3ddv]] – EfTA <br />
-
**[[3sxy]] – TmTA <br />
+
**[[3fms]], [[3sxy]] – TmTA <br />
**[[3c7j]] – PsTA <br />
**[[3c7j]] – PsTA <br />
-
**[[2p19]] – CgTA <br />
+
**[[2di3]], [[2p19]] – CgTA <br />
-
**[[3tqn]] – TA – ''Coxiella burnetii''<br />
+
**[[3tqn]] – TA –'' Coxiella burnetii''<br />
 +
**[[6za0]], [[6za3]], [[7za7]] – AfTA <br />
 +
**[[6z74]], [[6zab]] – AfTA + DNA<br />
 +
**[[7u5q]] – TA – ''Brucella melitensis''<br />
 +
**[[6sbs]] – SacTA <br />
 +
**[[3h5o]] – TA – ''Chromobacterium violaceum'' <br />
 +
**[[6az6]], [[7b5t]], [[7b5y]], [[7b5w]] – SaTA <br />
 +
**[[7b5u]] – SaTA + diAMP <br />
 +
**[[7oz3]] – SaTA + DNA – Cryo EM<br />
 +
**[[4r1h]] – LmTA <br />
 +
**[[3ihu]] – TA – ''Ralstonia eutropha'' <br />
 +
**[[3lhe]] – TA – ''Bacillus anthracis'' <br />
 +
**[[3f8m]] – MsTA <br />
-
*MarR family TA
+
*MarR family TA or multiple antibiotic resistance protein
**[[3boq]], [[3cjn]], [[3e6m]] – RpTA - ''Ruegeria pomeryi''<br />
**[[3boq]], [[3cjn]], [[3e6m]] – RpTA - ''Ruegeria pomeryi''<br />
**[[3s2w]] – TA – ''Methanosarcina mazei'' <br />
**[[3s2w]] – TA – ''Methanosarcina mazei'' <br />
-
**[[2fbk]] – DrTA – ''Deinococcus radiodurans''<br />
+
**[[3bpv]] – TA – ''Methanobacterium thermoautotrophicum'' <br />
 +
**[[2fbk]] – DrTA –'' Deinococcus radiodurans''<br />
**[[5dd8]] – DrTA (mutant) <br />
**[[5dd8]] – DrTA (mutant) <br />
**[[2fa5]] – TA – ''Xanthomonas campestris''<br />
**[[2fa5]] – TA – ''Xanthomonas campestris''<br />
-
**[[5aiq]] – NmTA <br />
+
**[[3g3z]], [[5aiq]] – NmTA <br />
**[[5aip]] – NmTA + hydroxyphenylacetate <br />
**[[5aip]] – NmTA + hydroxyphenylacetate <br />
**[[5e1w]] – DmTA – ''Dihalococcoides mccartyi''<br />
**[[5e1w]] – DmTA – ''Dihalococcoides mccartyi''<br />
**[[5e1z]], [[5e1x]], [[5e20]] – DmTA + phenol derivative <br />
**[[5e1z]], [[5e1x]], [[5e20]] – DmTA + phenol derivative <br />
-
**[[6c28]] – TA + coumaroyl-CoA – ''Rhodopseudomonas palustris'' <br />
+
**[[6c28]] – RpTA + coumaroyl-CoA – ''Rhodopseudomonas palustris'' <br />
**[[3fm5]] – RjTA <br />
**[[3fm5]] – RjTA <br />
**[[1z91]] – BsTA <br />
**[[1z91]] – BsTA <br />
 +
**[[4b8x]] – ScTA <br />
 +
**[[4yif]] – MtTA <br />
 +
**[[3vb2]], [[3voe]], [[4jba]] – EcTA <br />
 +
**[[3vod]] – EcTA (mutant)<br />
 +
**[[5h3r]] – EcTA (mutant) + DNA<br />
 +
**[[5eri]] – CdTA – ''Clostridium difficile''<br />
 +
**[[7dvn]] – TA + effector –'' Paenisporosarcina''<br />
 +
**[[3u2r]] – TA – ''Planctopirus limnophilus''<br />
 +
**[[2rdp]] – TA – ''Bacillus stearothermophilus''<br />
-
*MerR family TA
+
*MerR family TA or mercuric resistance operon regulatory protein
**[[3hh0]] – BcTA <br />
**[[3hh0]] – BcTA <br />
**[[3gpv]] – BtTA <br />
**[[3gpv]] – BtTA <br />
 +
**[[4ua1]], [[4ua2]] – TA – ''Bacillus megaterium''<br />
 +
**[[5crl]] – PaTA <br />
 +
**[[5gpe]] – TA – ''Cupriavidus metallidurans''<br />
 +
**[[3cnb]] – TA – ''Colwellia psychrerythraea'' <br />
 +
**[[6d90]] – HiTA – ''Haemophilia influenzae''<br />
 +
**[[5d8c]] – HiTA + DNA <br />
 +
**[[6xl6]], [[6xla]], [[6xlk]] – EcTA + DNA – Cryo EM<br />
 +
**[[6xl5]], [[6xl9]], [[6xlj]] – EcTA in RNP complex – Cryo EM<br />
*AsnC family TA
*AsnC family TA
**[[3i4p]] – AfTA <br />
**[[3i4p]] – AfTA <br />
 +
**[[2cg4]] – EcTA <br />
-
*AraC family TA
+
*AraC family TA or arabinose operon regulatory protein
**[[3gra]] – PpTA – ''Pseudomonas putida''<br />
**[[3gra]] – PpTA – ''Pseudomonas putida''<br />
**[[3cu5]] – TA – ''Lacnoclostridium phytofermentans''<br />
**[[3cu5]] – TA – ''Lacnoclostridium phytofermentans''<br />
**[[5chh]] – PaTA <br />
**[[5chh]] – PaTA <br />
 +
**[[2ara]] – EcTA <br />
 +
**[[1xja]] – EcTA dimerization domain (mutant)<br />
 +
**[[2k9s]] – EcTA DBD - NMR<br />
 +
**[[2arc]] – EcTA + arabinose<br />
 +
**[[2aac]] – EcTA + fucose<br />
*LacI family TA
*LacI family TA
Line 337: Line 351:
**[[5zhv]], [[5zi8]], [[5zhc]] – MtTA <br />
**[[5zhv]], [[5zi8]], [[5zhc]] – MtTA <br />
**[[5zqh]] – SpTA <br />
**[[5zqh]] – SpTA <br />
-
**[[5x12]] – BsTA <br />
+
**[[5x12]], [[7cbv]] – BsTA <br />
-
**[[5y8t]] – BsTA + coumaric acid<br />
+
**[[5x13]], [[5y8t]] – BsTA + coumaric acid<br />
 +
**[[5x14]] – BsTA + ferulic acid<br />
 +
**[[6abq]], [[6abt]] – LmTA <br />
 +
**[[5dym]] – CdTA <br />
-
*TrmB TA
+
*TrmB TA or tRNA (guanine-N(7)-) methyltransferase
-
**[[2f5t]] – TA – Thermococcus litoralis<br />
+
**[[2f5t]] – TA – ''Thermococcus litoralis''<br />
 +
**[[3qph]] – PfTA + sucrose – ''Pyrococcus furiosus''<br />
*IclR TA
*IclR TA
**[[1mkm]] – TmTA <br />
**[[1mkm]] – TmTA <br />
-
 
+
**[[2o99]], [[2o9a]] – EcTA C-terminal <br />
 +
**[[1td5]] – EcTA LBD <br />
 +
**[[7cuo]] – TA + hydroxybenzoate – ''Microbacterium hydrocarbonoxydans <br />
 +
''
*BgaR TA
*BgaR TA
Line 358: Line 379:
**[[3qpt]] – StTA <br />
**[[3qpt]] – StTA <br />
**[[3q5f]] – StTA + DNA <br />
**[[3q5f]] – StTA + DNA <br />
-
**[[4aih]] – YpTA – Yersinia pseudotuberculosis<br />
+
**[[4aih]] – YpTA – ''Yersinia pseudotuberculosis''<br />
**[[4aij]], [[4aik]] – YpTA + DNA <br />
**[[4aij]], [[4aik]] – YpTA + DNA <br />
- 
-
*BenM TA
 
- 
-
**[[3k1n]] – AbTA – ''Acinetobacter baylyi''<br />
 
-
**[[3k1p]] – AbTA (mutant)<br />
 
-
**[[2f6g]], [[2f6p]], [[2f97]] – AbTA effector-binding domain 81-304<br />
 
-
**[[3m1e]] – AbTA DBD 1-87<br />
 
-
**[[4ihs]], [[4iht]] – AbTA effector-binding domain + DNA <br />
 
-
**[[2f78]], [[2f7a]], [[2f7c]] – AbTA effector-binding domain + effector <br />
 
-
**[[2h9b]] – EfTA (mutant)<br />
 
- 
-
*CatM TA
 
- 
-
**[[2f7b]], [[2h98]] – AbTA effector-binding domain <br />
 
*CouR TA
*CouR TA
-
**[[5cyv]] – RjTA + coumaroyl-CoA – ''Rhodococcus jostii''<br />
+
**[[5cyv]], [[6c28]] – RjTA + coumaroyl-CoA –'' Rhodococcus jostii''<br />
-
 
+
**[[6c9t]] – RpTA <br />
-
*MgrA TA
+
**[[6c2s]] – RpTA + DNA <br />
-
 
+
-
**[[2bv6]] – SaTA – ''Staphylococcus aureus''<br />
+
-
 
+
-
*SarX TA
+
-
 
+
-
**[[5hs5]], [[5ywj]], [[6k8e]] – SaTA <br />
+
-
 
+
-
*QacR TA
+
-
 
+
-
**[[2gby]] – SaTA <br />
+
-
**[[3br6]] – SaTA (mutant) + rhodamine<br />
+
-
**[[3bqz]] – SaTA + malachite green<br />
+
-
**[[3br1]], [[3br2]] – SaTA (mutant) + dequalinium<br />
+
-
**[[2g0e]] – TA + drug – ''Staphylococcus haemolyticus''<br />
+
-
 
+
-
*AcrR TA
+
-
 
+
-
**[[2qop]] – EcTA <br />
+
*CueR TA
*CueR TA
**[[1q07]], [[1q06]], [[1q05]] – EcTA <br />
**[[1q07]], [[1q06]], [[1q05]] – EcTA <br />
- 
-
*PurR TA
 
- 
-
**[[3d8u]] – VpTA – ''Vibrio parahaemolyticus''<br />
 
*LuxR TA
*LuxR TA
Line 414: Line 399:
*LuxT TA
*LuxT TA
-
**[[3ljl]] – VpTA <br />
+
**[[3b4s]], [[3ljl]] – VpTA <br />
-
*ClgR TA
+
*ClgR TA or Clp gene regulator
**[[5woq]] – MsTA <br />
**[[5woq]] – MsTA <br />
 +
**[[3f51]], [[3f52]] – CgTA <br />
*LmrR TA
*LmrR TA
Line 426: Line 412:
**[[6vwe]], [[6do0]] – LlTA + Rh complex<br />
**[[6vwe]], [[6do0]] – LlTA + Rh complex<br />
**[[6r1l]] – LlTA + Cu + phenanthroline<br />
**[[6r1l]] – LlTA + Cu + phenanthroline<br />
 +
**[[4zzd]] – LlTA + riboflavine<br />
 +
**[[6fuu]] – LlTA + heme<br />
*MvfR TA
*MvfR TA
-
**[[6z17]] – PaTA <br />
+
**[[4jvc]], [[6z17]] – PaTA <br />
-
**[[6z5k]] – PaTA + inhibitor<br />
+
**[[4jvd]], [[4jvi]], [[6q7u]], [[6q7v]], [[6tpr]], [[6yiz]], [[6yz3]], [[6z07]], **[[6z17]], [[6z5k]], [[7nbw]], [[7o2t]], [[7o2u]] – PaTA + inhibitor<br />
 +
**[[6b8a]], [[6q7w]] – PaTA LBD 94-295 + inhibitor<br />
*HdfR TA
*HdfR TA
Line 439: Line 428:
**[[4p9f]] – EcTA <br />
**[[4p9f]] – EcTA <br />
 +
**[[4ab5]] – MnTA <br />
 +
**[[4ab6]] – MnTA (mutant)<br />
*MetR TA
*MetR TA
Line 444: Line 435:
**[[5fo5]] – EcTA DBD<br />
**[[5fo5]] – EcTA DBD<br />
-
*McbR TA
+
*YvhJ TA
**[[3nxh]] – BsTA <br />
**[[3nxh]] – BsTA <br />
Line 450: Line 441:
*CgmR TA
*CgmR TA
-
**[[2zoy]] – CgTA <br />
+
**[[2yve]], [[2zoy]] – CgTA <br />
**[[2zoz]] – CgTA + ethidium<br />
**[[2zoz]] – CgTA + ethidium<br />
 +
**[[2yvh]] – CgTA + DNA<br />
-
*AraR TA
+
*AraR TA or arabinose metabolism transcriptional repressor
-
**[[5bs6]] – TA – ''Bacterioides thetaiotaomicron''<br />
+
**[[5bs6]], [[5dd4]] – BtTA – ''Bacterioides thetaiotaomicron''<br />
 +
**[[3tb6]] – BtTA effector-binding domain 71-362 + arabinose<br />
 +
**[[5ddg]] – BtTA + DNA<br />
 +
**[[5deq]] – BtTA 1-225 + arabinose<br />
 +
**[[4egy]], [[4egz]], [[4h0e]], [[5d4r]], [[5d4s]] – BsTA DBD 1-68 + DNA<br />
-
*CarH TA
+
*CarH TA or light-dependent transcriptional regulator
-
**[[5c8d]] – TtTA + adnosylcobalamin<br />
+
**[[5c8a]], [[5c8d]], [[5c8e]], [[5c8f]] – TtTA + cobalamin derivative<br />
-
*ZitR TA
+
*ZitR TA or zinc transport transcriptional regulator
-
**[[5yhy]], [[5yi0]], [[5yi1]] – LlTA (mutant)<br />
+
**[[5yhx]] – LlTA <br />
 +
**[[5yhy]], [[5yhz]], [[5yi0]], [[5yi1]], [[6fi9]] – LlTA (mutant)<br />
 +
**[[5yi2]] – LlTA + DNA<br />
 +
**[[5yi3]] – LlTA (mutant) + DNA<br />
*LsrR TA
*LsrR TA
Line 470: Line 469:
**[[4l4z]], [[4l50]], [[4l51]], [[4l5i]], [[4l5j]] – EcTA + ligand<br />
**[[4l4z]], [[4l50]], [[4l51]], [[4l5i]], [[4l5j]] – EcTA + ligand<br />
-
*HTH-type TA
+
*TA II
 +
 
 +
**[[8igr]] – EcTA in transcription activation complex – Cryo EM<br />
 +
 
 +
*TA RAMA
 +
 
 +
**[[7bef]], [[7beg]] – EcTA in transcription activation complex – Cryo EM<br />
 +
 
 +
*PrfA TA or listeriolysin positive regulatory factor A
 +
 
 +
**[[1omi]], [[2beo]] – LmTA <br />
 +
**[[2bgc]], [[6qvy]], [[6qvz]], [[6qw1]], [[6qw2]] – LmTA (mutant) <br />
 +
**[[5lej]], [[5x6d]] – LmTA + DNA<br />
 +
**[[5lek]], [[6qwf]], [[6qwh]], [[6qwk]], [[6qwm]] – LmTA (mutant) + DNA <br />
 +
**[[5f1r]], [[6eut]], [[6euu]], [[6euz]], [[6ev0]], [[6exk]], [[6exl]], [[6exm]], [[6t5i]] – LmTA + inhibitor<br />
 +
**[[5lrs]], [[5x6e]] – LmTA + DNA + glutathione<br />
 +
**[[5lrr]] – LmTA + glutathione<br />
 +
**[[6hck]] – LmTA + peptide<br />
 +
 
 +
*HTH-type TA or helix-turn-helix-type
**[[2uxu]] – PpTA TtgR + naringenin<br />
**[[2uxu]] – PpTA TtgR + naringenin<br />
**[[2uxh]] – PpTA TtgR + quercetin<br />
**[[2uxh]] – PpTA TtgR + quercetin<br />
**[[2uxi]] – PpTA TtgR + phloretin<br />
**[[2uxi]] – PpTA TtgR + phloretin<br />
-
**[[6ugl]], [[6kju]] – VcTA + pyrazine derivative<br />
+
**[[6ugl]], [[6kju]] – VcTA + pyrazine derivative<''br />
 +
**[[2bv6]] – SaTA MgrA –'' Staphylococcus aureus<br />
 +
**[[5hs5]], [[5ywj]], [[6k8e]] – SaTA SarX<br />
**[[3hrm]], [[3hse]] – SaTA SarZ <br />
**[[3hrm]], [[3hse]] – SaTA SarZ <br />
**[[6r1p]] – MtTA EthR <br />
**[[6r1p]] – MtTA EthR <br />
**[[1ysq]] – EcTA YiaJ <br />
**[[1ysq]] – EcTA YiaJ <br />
 +
**[[2qop]], [[3bcg]] – EcTA AcrR<br />
 +
**[[6ldi]], [[6xh7]], [[6xh8]], [[7c17]] – EcTA CueR in transcription activation complex – Cryo EM <br />
 +
**[[4wls]], [[4wlw]] – EcTA CueR + DNA<br />
 +
**[[4x1e]] – EcTA RutR<br />
 +
**[[4xk4]], [[4jyk]] – EcTA RutR + uracil derivative<br />
 +
**[[2hxr]] – EcTA CynR LBD <br />
 +
**[[3hfu]] – EcTA CynR LBD + N3<br />
 +
**[[8bob]] – EcTA MalT + MalY – Cryo EM <br />
**[[2gfn]] – RjTA Rha1 <br />
**[[2gfn]] – RjTA Rha1 <br />
-
**[[1i1g]] – TA LrpA – ''Pyrococcus furiosus''<br />
+
**[[1i1g]] – PfTA LrpA <br />
**[[7cla]] – TA SkgA – ''Caulobacter vibrioides''<br />
**[[7cla]] – TA SkgA – ''Caulobacter vibrioides''<br />
-
 
+
**[[7bzd]] – BsTA HxlR <br />
 +
**[[7bze]] – BsTA HxlR (mutant)<br />
 +
**[[7bzg]] – BsTA HxlR + DNA<br />
 +
**[[7amn]], [[7amt]] – TA LuxR + DNA – ''Vibrio alginolyticus''<br />
 +
**[[2dtz]], [[2hq5]] – SaTA QacR (mutant)<br />
 +
**[[3bqz]], [[3br0]], [[3btc]], [[3btl]] – SaTA QacR (mutant) + malachite green<br />
 +
**[[3br1]], [[3br2]], [[3bt9]], [[3btj]] – SaTA QacR (mutant) + dequalinium<br />
 +
**[[3bti]] – SaTA QacR (mutant) + berberine<br />
 +
**[[1qvu]],[[3br3]], [[3pm1]] – SaTA QacR (mutant) + ethidium<br />
 +
**[[1rkw]], [[1rpw]] – SaTA QacR (mutant) + pentamadine<br />
 +
**[[1qvt]] – SaTA QacR (mutant) + proflavine<br />
 +
**[[3br5]], [[3br6]] – SaTA QacR (mutant) + rhodamine<br />
 +
**[[2gby]] – SaTA QacR (mutant) + berenil<br />
 +
**[[2g0e]] – SaTA QacR (mutant) + drug<br />
 +
**[[3k1n]] – AbTA BenM – Acinetobacter baylyi<br />
 +
**[[3k1p]] – AbTA BenM (mutant)<br />
 +
**[[2f6g]], [[2f6p]], [[2f97]] – AbTA BenM effector-binding domain 81-304<br />
 +
**[[3m1e]] – AbTA BenM DBD 1-87<br />
 +
**[[4ihs]], [[4iht]] – AbTA BenM effector-binding domain + DNA <br />
 +
**[[2f78]], [[2f7a]], [[2f7c]] – AbTA BenM effector-binding domain + effector <br />
 +
**[[2h9b]] – EfTA BenM (mutant)<br />
 +
**[[2f7b]], [[2h98]] – AbTA CatM effector-binding domain <br />
 +
**[[3glb]] – AbTA CatM effector-binding domain (mutant)<br />
 +
**[[2f7c]] – AbTA CatM effector-binding domain + muconate<br />
 +
**[[2cfx]] – BsTA LrpC<br />
 +
**[[2gqq]] – EcTA LrpC<br />
 +
**[[6d2s]], [[6cyj]], [[6cz6]], [[6cyy]] – MtTA PrpR<br />
 +
**[[2pju]] – EcTA PrpR<br />
 +
**[[5t4k]], [[5t4j]], [[5t4l]], [[5x03]] – BsTA GabR EBO domain + pyridine derivative<br />
 +
**[[4mgr]], [[4nob]], [[4tv7]] – BsTA GabR <br />
 +
**[[6uxz]] – BsTA GabR + agonist<br />
 +
**[[5u9e]], [[5u93]] – TA RhaR regulatory domain – ''Bacteria latreille''<br />
 +
**[[5z49]] – TA CmpR effector-binding domain + ribulose bisphosphate – ''Synechococcus elongatus''<br />
 +
**[[3kos]] – CfTA AmpR effector binding domain – ''Citrobacter freundii''<br />
 +
**[[3kot]] – CfTA AmpR effector binding domain (mutant)<br />
 +
**[[4wkm]] – CfTA AmpR effector binding domain + peptide<br />
 +
**[[5mmh]] – PaTA AmpR effector binding domain <br />
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

3D Structures of transcriptional activator

Updated on 01-January-2024 - For a general description of the protein see Transcriptional activator

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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