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Treatment of Tuberculosis
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| - | <StructureSection load='' size=' | + | <StructureSection load='' size='350' side='right' scene='Journal:JBSD:11/Cv/4' caption=''> |
=== Drug Pyrazinamide | Target pyrazinamidase === | === Drug Pyrazinamide | Target pyrazinamidase === | ||
'''Drug resistance mechanism of PncA in ''Mycobacterium Tuberculosis''<ref>doi 10.1080/07391102.2012.759885</ref>''' | '''Drug resistance mechanism of PncA in ''Mycobacterium Tuberculosis''<ref>doi 10.1080/07391102.2012.759885</ref>''' | ||
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=== Drug Triclosan | Target Enoyl-Acyl-Carrier Protein Reductase=== | === Drug Triclosan | Target Enoyl-Acyl-Carrier Protein Reductase=== | ||
[[Enoyl-Acyl-Carrier Protein Reductase]] is a target of anti-bacterial drugs such as triclosan (TCL)<ref>PMID:19130456</ref>. These drugs are used against tuberculosis infection. <scene name='43/434541/Cv/10'>Enoyl-Acyl-Carrier Protein Reductase is a tetramer</scene> (PDB code [[3fne]]). InhA ENR <scene name='43/434541/Cv/11'>active site contains NAD and triclosan derivative</scene>. | [[Enoyl-Acyl-Carrier Protein Reductase]] is a target of anti-bacterial drugs such as triclosan (TCL)<ref>PMID:19130456</ref>. These drugs are used against tuberculosis infection. <scene name='43/434541/Cv/10'>Enoyl-Acyl-Carrier Protein Reductase is a tetramer</scene> (PDB code [[3fne]]). InhA ENR <scene name='43/434541/Cv/11'>active site contains NAD and triclosan derivative</scene>. | ||
| - | </StructureSection> | ||
| + | === Drug [[Bedaquiline]] | Target proton pump for ATP synthase of mycobacteria === | ||
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| + | === Drug [[Ethambutol]] | Target Mycobacterium tuberculosis arabinosyltransferase === | ||
| + | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category: Topic Page]] | [[Category: Topic Page]] | ||
| - | [[Category: Treatment]] | ||
Current revision
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References
- ↑ Rajendran V, Sethumadhavan R. Drug resistance mechanism of PncA in Mycobacterium tuberculosis. J Biomol Struct Dyn. 2013 Feb 6. PMID:23383724 doi:10.1080/07391102.2012.759885
- ↑ Freundlich JS, Wang F, Vilcheze C, Gulten G, Langley R, Schiehser GA, Jacobus DP, Jacobs WR Jr, Sacchettini JC. Triclosan Derivatives: Towards Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis. ChemMedChem. 2009 Jan 7. PMID:19130456 doi:10.1002/cmdc.200800261
