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4up0
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==Ternary crystal structure of the Pygo2 PHD finger in complex with the B9L HD1 domain and a H3K4me2 peptide== | ==Ternary crystal structure of the Pygo2 PHD finger in complex with the B9L HD1 domain and a H3K4me2 peptide== | ||
| - | <StructureSection load='4up0' size='340' side='right' caption='[[4up0]], [[Resolution|resolution]] 1.28Å' scene=''> | + | <StructureSection load='4up0' size='340' side='right'caption='[[4up0]], [[Resolution|resolution]] 1.28Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4up0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UP0 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4up0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UP0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UP0 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.28Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4up0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4up0 OCA], [https://pdbe.org/4up0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4up0 RCSB], [https://www.ebi.ac.uk/pdbsum/4up0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4up0 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/PYGO2_HUMAN PYGO2_HUMAN] Involved in signal transduction through the Wnt pathway.[https://www.uniprot.org/uniprot/BCL9L_HUMAN BCL9L_HUMAN] Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Bienz M]] |
| - | + | [[Category: Birchall K]] | |
| - | [[Category: | + | [[Category: Chugh J]] |
| - | [[Category: | + | [[Category: Fiedler M]] |
| - | [[Category: | + | [[Category: Miller TCR]] |
| - | [[Category: | + | [[Category: Rutherford TJ]] |
| - | [[Category: | + | |
| - | + | ||
| - | + | ||
Current revision
Ternary crystal structure of the Pygo2 PHD finger in complex with the B9L HD1 domain and a H3K4me2 peptide
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