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4uu3
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Ferulic acid decarboxylase from Enterobacter sp.== | |
| + | <StructureSection load='4uu3' size='340' side='right'caption='[[4uu3]], [[Resolution|resolution]] 1.15Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4uu3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterobacter_sp. Enterobacter sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UU3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UU3 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.15Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uu3 OCA], [https://pdbe.org/4uu3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uu3 RCSB], [https://www.ebi.ac.uk/pdbsum/4uu3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uu3 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/C6F3U5_9ENTR C6F3U5_9ENTR] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | We report on a 'green' method for the utilization of carbon dioxide as C1 unit for the regioselective synthesis of (E)-cinnamic acids via regioselective enzymatic carboxylation of para-hydroxystyrenes. Phenolic acid decarboxylases from bacterial sources catalyzed the beta-carboxylation of para-hydroxystyrene derivatives with excellent regio- and (E/Z)-stereoselectivity by exclusively acting at the beta-carbon atom of the C=C side chain to furnish the corresponding (E)-cinnamic acid derivatives in up to 40% conversion at the expense of bicarbonate as carbon dioxide source. Studies on the substrate scope of this strategy are presented and a catalytic mechanism is proposed based on molecular modelling studies supported by mutagenesis of amino acid residues in the active site. | ||
| - | + | Regioselective Enzymatic beta-Carboxylation of -Hydroxy- styrene Derivatives Catalyzed by Phenolic Acid Decarboxylases.,Wuensch C, Pavkov-Keller T, Steinkellner G, Gross J, Fuchs M, Hromic A, Lyskowski A, Fauland K, Gruber K, Glueck SM, Faber K Adv Synth Catal. 2015 May 26;357(8):1909-1918. Epub 2015 Apr 2. PMID:26190963<ref>PMID:26190963</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 4uu3" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Enterobacter sp]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Hromic | + | [[Category: Faber K]] |
| - | [[Category: | + | [[Category: Fauland K]] |
| - | [[Category: Pavkov-Keller | + | [[Category: Fuchs M]] |
| - | [[Category: | + | [[Category: Glueck SM]] |
| + | [[Category: Gross J]] | ||
| + | [[Category: Gruber K]] | ||
| + | [[Category: Hromic A]] | ||
| + | [[Category: Lyskowski A]] | ||
| + | [[Category: Pavkov-Keller T]] | ||
| + | [[Category: Steinkellner G]] | ||
| + | [[Category: Wuensch C]] | ||
Current revision
Ferulic acid decarboxylase from Enterobacter sp.
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Categories: Enterobacter sp | Large Structures | Faber K | Fauland K | Fuchs M | Glueck SM | Gross J | Gruber K | Hromic A | Lyskowski A | Pavkov-Keller T | Steinkellner G | Wuensch C
