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4v11

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==Structure of Synaptotagmin-1 with SV2A peptide phosphorylated at Thr84==
==Structure of Synaptotagmin-1 with SV2A peptide phosphorylated at Thr84==
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<StructureSection load='4v11' size='340' side='right' caption='[[4v11]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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<StructureSection load='4v11' size='340' side='right'caption='[[4v11]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4v11]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V11 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V11 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4v11]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V11 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V11 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v11 OCA], [http://pdbe.org/4v11 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4v11 RCSB], [http://www.ebi.ac.uk/pdbsum/4v11 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4v11 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v11 OCA], [https://pdbe.org/4v11 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v11 RCSB], [https://www.ebi.ac.uk/pdbsum/4v11 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v11 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SYT1_HUMAN SYT1_HUMAN]] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. [[http://www.uniprot.org/uniprot/SV2A_HUMAN SV2A_HUMAN]] Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity).
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[https://www.uniprot.org/uniprot/SYT1_HUMAN SYT1_HUMAN] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4v11" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4v11" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Synaptotagmin 3D structures|Synaptotagmin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Alessi, D R]]
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[[Category: Homo sapiens]]
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[[Category: Campbell, D]]
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[[Category: Large Structures]]
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[[Category: Cousin, M A]]
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[[Category: Alessi DR]]
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[[Category: Esoof, N]]
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[[Category: Campbell D]]
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[[Category: Fritsch, M J]]
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[[Category: Cousin MA]]
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[[Category: Gordon, S L]]
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[[Category: Esoof N]]
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[[Category: Gourlay, R]]
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[[Category: Fritsch MJ]]
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[[Category: Macartney, T]]
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[[Category: Gordon SL]]
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[[Category: Peggie, M]]
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[[Category: Gourlay R]]
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[[Category: Velupillai, S]]
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[[Category: Macartney T]]
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[[Category: Zhang, N]]
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[[Category: Peggie M]]
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[[Category: VanAalten, D M.F]]
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[[Category: Velupillai S]]
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[[Category: Signaling protein]]
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[[Category: Zhang N]]
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[[Category: VanAalten DMF]]

Current revision

Structure of Synaptotagmin-1 with SV2A peptide phosphorylated at Thr84

PDB ID 4v11

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