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4wk9

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==Crystal structure of human chitotriosidase-1 catalytic domain in complex with chitobiose (0.3mM) at 1.10 A resolution==
==Crystal structure of human chitotriosidase-1 catalytic domain in complex with chitobiose (0.3mM) at 1.10 A resolution==
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<StructureSection load='4wk9' size='340' side='right' caption='[[4wk9]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
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<StructureSection load='4wk9' size='340' side='right'caption='[[4wk9]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4wk9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WK9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WK9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4wk9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WK9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WK9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CBS:DI(N-ACETYL-D-GLUCOSAMINE)'>CBS</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.102&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CHIT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wk9 OCA], [https://pdbe.org/4wk9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wk9 RCSB], [https://www.ebi.ac.uk/pdbsum/4wk9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wk9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wk9 OCA], [http://pdbe.org/4wk9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wk9 RCSB], [http://www.ebi.ac.uk/pdbsum/4wk9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wk9 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CHIT1_HUMAN CHIT1_HUMAN]] Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity.<ref>PMID:7592832</ref> <ref>PMID:7836450</ref> <ref>PMID:9748235</ref>
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[https://www.uniprot.org/uniprot/CHIT1_HUMAN CHIT1_HUMAN] Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity.<ref>PMID:7592832</ref> <ref>PMID:7836450</ref> <ref>PMID:9748235</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4wk9" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4wk9" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Chitinase 3D structures|Chitinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chitinase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Cachau, R]]
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[[Category: Cachau R]]
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[[Category: Cousido-Siah, A]]
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[[Category: Cousido-Siah A]]
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[[Category: Fadel, F]]
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[[Category: Fadel F]]
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[[Category: Harlos, K]]
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[[Category: Harlos K]]
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[[Category: Howard, E]]
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[[Category: Howard E]]
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[[Category: Mitschler, A]]
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[[Category: Mitschler A]]
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[[Category: Podjarny, A]]
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[[Category: Podjarny A]]
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[[Category: Ruiz, F X]]
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[[Category: Ruiz FX]]
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[[Category: Zhao, Y]]
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[[Category: Zhao Y]]
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[[Category: Catalytic mechanism]]
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[[Category: Chit1]]
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[[Category: Gh18 chitinase]]
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[[Category: Hydrolase]]
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[[Category: Hydrolysis]]
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[[Category: Protonation state]]
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Current revision

Crystal structure of human chitotriosidase-1 catalytic domain in complex with chitobiose (0.3mM) at 1.10 A resolution

PDB ID 4wk9

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