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4wxg

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==Crystal structure of L-Serine Hydroxymethyltransferase in complex with a mixture of L-allo-Threonine and Glycine==
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==Crystal structure of L-Serine Hydroxymethyltransferase in complex with a mixture of L-Threonine and Glycine==
<StructureSection load='4wxg' size='340' side='right'caption='[[4wxg]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='4wxg' size='340' side='right'caption='[[4wxg]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4wxg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Strt1 Strt1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WXG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WXG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4wxg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_thermophilus_CNRZ1066 Streptococcus thermophilus CNRZ1066]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WXG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WXG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2BO:N-({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)-L-THREONINE'>2BO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">glyA, str0755 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=299768 STRT1])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2BO:N-({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)-L-THREONINE'>2BO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_hydroxymethyltransferase Glycine hydroxymethyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.1 2.1.2.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wxg OCA], [https://pdbe.org/4wxg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wxg RCSB], [https://www.ebi.ac.uk/pdbsum/4wxg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wxg ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wxg OCA], [http://pdbe.org/4wxg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wxg RCSB], [http://www.ebi.ac.uk/pdbsum/4wxg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wxg ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GLYA_STRT1 GLYA_STRT1]] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
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[https://www.uniprot.org/uniprot/GLYA_STRT1 GLYA_STRT1] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Serine hydroxymethyltransferase|Serine hydroxymethyltransferase]]
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*[[Serine hydroxymethyltransferase 3D structures|Serine hydroxymethyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Glycine hydroxymethyltransferase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Strt1]]
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[[Category: Streptococcus thermophilus CNRZ1066]]
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[[Category: Bujons, J]]
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[[Category: Bujons J]]
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[[Category: Clapes, P]]
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[[Category: Clapes P]]
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[[Category: Hernandez, K]]
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[[Category: Hernandez K]]
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[[Category: Joglar, J]]
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[[Category: Joglar J]]
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[[Category: Parella, T]]
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[[Category: Parella T]]
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[[Category: Petrillo, G]]
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[[Category: Petrillo G]]
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[[Category: Uson, I]]
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[[Category: Uson I]]
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[[Category: Wandtke, C]]
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[[Category: Wandtke C]]
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[[Category: Zelen, I]]
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[[Category: Zelen I]]
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[[Category: Aldehyde]]
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[[Category: Aldolase]]
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[[Category: Catalysis]]
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[[Category: Catalytic domain]]
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[[Category: Dimerization]]
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[[Category: L-allo-threonine]]
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[[Category: Protein binding]]
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[[Category: Threonine aldolase]]
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[[Category: Transferase]]
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Current revision

Crystal structure of L-Serine Hydroxymethyltransferase in complex with a mixture of L-Threonine and Glycine

PDB ID 4wxg

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