4xjw

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<StructureSection load='4xjw' size='340' side='right'caption='[[4xjw]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
<StructureSection load='4xjw' size='340' side='right'caption='[[4xjw]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4xjw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strpn Strpn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XJW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XJW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4xjw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XJW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XJW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=OPX:(1S,3R,4S)-1-[(CYCLOHEXYLAMINO)METHYL]-3,4-DIHYDROXYCYCLOPENTANESULFONIC+ACID'>OPX</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.53&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">nanB, SP_1687 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=170187 STRPN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=OPX:(1S,3R,4S)-1-[(CYCLOHEXYLAMINO)METHYL]-3,4-DIHYDROXYCYCLOPENTANESULFONIC+ACID'>OPX</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xjw OCA], [https://pdbe.org/4xjw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xjw RCSB], [https://www.ebi.ac.uk/pdbsum/4xjw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xjw ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xjw OCA], [http://pdbe.org/4xjw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xjw RCSB], [http://www.ebi.ac.uk/pdbsum/4xjw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xjw ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NANB_STRPN NANB_STRPN]
==See Also==
==See Also==
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*[[Sialidase|Sialidase]]
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*[[Neuraminidase 3D structures|Neuraminidase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Exo-alpha-sialidase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Strpn]]
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[[Category: Streptococcus pneumoniae TIGR4]]
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[[Category: Brear, P]]
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[[Category: Brear P]]
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[[Category: Allosteric inhibitor]]
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[[Category: Crystallization artefact]]
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[[Category: Drug design]]
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[[Category: Glycosidase]]
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[[Category: Hydrolase]]
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[[Category: Intramolecular trans-sialidase]]
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[[Category: Neuraminidase]]
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[[Category: Serendipitous allosteric site]]
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Current revision

Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with Optactin at pH 7.4 in PBS with DMSO as the cryoprotectant

PDB ID 4xjw

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