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4xz2

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==Human platelet phosphofructokinase in an R-state in complex with ADP and F6P, crystal form I==
==Human platelet phosphofructokinase in an R-state in complex with ADP and F6P, crystal form I==
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<StructureSection load='4xz2' size='340' side='right' caption='[[4xz2]], [[Resolution|resolution]] 2.67&Aring;' scene=''>
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<StructureSection load='4xz2' size='340' side='right'caption='[[4xz2]], [[Resolution|resolution]] 2.67&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4xz2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XZ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XZ2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4xz2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XZ2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=F6P:FRUCTOSE-6-PHOSPHATE'>F6P</scene>, <scene name='pdbligand=FBP:BETA-FRUCTOSE-1,6-DIPHOSPHATE'>FBP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.67&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wlo|4wlo]], [[4u1r|4u1r]], [[4rh3|4rh3]], [[4omt|4omt]], [[3opy|3opy]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=F6P:FRUCTOSE-6-PHOSPHATE'>F6P</scene>, <scene name='pdbligand=FBP:BETA-FRUCTOSE-1,6-DIPHOSPHATE'>FBP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6-phosphofructokinase 6-phosphofructokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.11 2.7.1.11] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xz2 OCA], [https://pdbe.org/4xz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xz2 RCSB], [https://www.ebi.ac.uk/pdbsum/4xz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xz2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xz2 OCA], [http://pdbe.org/4xz2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xz2 RCSB], [http://www.ebi.ac.uk/pdbsum/4xz2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xz2 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PFKAP_HUMAN PFKAP_HUMAN]] Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
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[https://www.uniprot.org/uniprot/PFKAP_HUMAN PFKAP_HUMAN] Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4xz2" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4xz2" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Phosphofructokinase 3D structures|Phosphofructokinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 6-phosphofructokinase]]
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[[Category: Homo sapiens]]
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[[Category: Kloos, M]]
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[[Category: Large Structures]]
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[[Category: Strater, N]]
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[[Category: Kloos M]]
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[[Category: Fructose 6-phosphate]]
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[[Category: Strater N]]
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[[Category: Human platelet phosphofructokinase]]
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[[Category: Main regulator of glycolysis]]
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[[Category: Transferase]]
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Current revision

Human platelet phosphofructokinase in an R-state in complex with ADP and F6P, crystal form I

PDB ID 4xz2

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