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4zfl

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==Ergothioneine-biosynthetic Ntn hydrolase variant EgtC_C2A with natural substrate==
==Ergothioneine-biosynthetic Ntn hydrolase variant EgtC_C2A with natural substrate==
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<StructureSection load='4zfl' size='340' side='right' caption='[[4zfl]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='4zfl' size='340' side='right'caption='[[4zfl]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4zfl]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZFL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZFL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4zfl]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZFL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZFL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4NK:(1S)-1-CARBOXY-4-({(1R)-1-CARBOXY-2-[(S)-{4-[(2S)-2-CARBOXY-2-(TRIMETHYLAMMONIO)ETHYL]-1H-IMIDAZOL-2-YL}SULFINYL]ETHYL}AMINO)-4-OXOBUTAN-1-AMINIUM'>4NK</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zfj|4zfj]], [[4zfk|4zfk]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4NK:(1S)-1-CARBOXY-4-({(1R)-1-CARBOXY-2-[(S)-{4-[(2S)-2-CARBOXY-2-(TRIMETHYLAMMONIO)ETHYL]-1H-IMIDAZOL-2-YL}SULFINYL]ETHYL}AMINO)-4-OXOBUTAN-1-AMINIUM'>4NK</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zfl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfl OCA], [http://pdbe.org/4zfl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zfl RCSB], [http://www.ebi.ac.uk/pdbsum/4zfl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zfl ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zfl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfl OCA], [https://pdbe.org/4zfl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zfl RCSB], [https://www.ebi.ac.uk/pdbsum/4zfl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zfl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/EGTC_MYCS2 EGTC_MYCS2]] Catalyzes the hydrolysis of the gamma-glutamyl amide bond from N-(gamma-glutamyl)-[N(alpha),N(alpha),N(alpha)-trimethyl-L-histidinyl]-cysteine sulfoxide to produce hercynylcysteine sulfoxide.<ref>PMID:20420449</ref>
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[https://www.uniprot.org/uniprot/EGTC_MYCS2 EGTC_MYCS2] Catalyzes the hydrolysis of the gamma-glutamyl amide bond from N-(gamma-glutamyl)-[N(alpha),N(alpha),N(alpha)-trimethyl-L-histidinyl]-cysteine sulfoxide to produce hercynylcysteine sulfoxide.<ref>PMID:20420449</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Blankenfeldt, W]]
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[[Category: Large Structures]]
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[[Category: Seebeck, F P]]
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[[Category: Mycolicibacterium smegmatis MC2 155]]
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[[Category: Vit, A]]
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[[Category: Blankenfeldt W]]
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[[Category: Ergothioneine biosynthesis]]
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[[Category: Seebeck FP]]
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[[Category: Hydrolase]]
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[[Category: Vit A]]
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[[Category: Mycobacteria]]
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[[Category: Ntn hydrolase]]
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[[Category: Sulfur chemistry]]
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Current revision

Ergothioneine-biosynthetic Ntn hydrolase variant EgtC_C2A with natural substrate

PDB ID 4zfl

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