4zgm

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==Crystal structure of Semaglutide peptide backbone in complex with the GLP-1 receptor extracellular domain==
==Crystal structure of Semaglutide peptide backbone in complex with the GLP-1 receptor extracellular domain==
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<StructureSection load='4zgm' size='340' side='right' caption='[[4zgm]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='4zgm' size='340' side='right'caption='[[4zgm]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4zgm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZGM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZGM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4zgm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZGM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZGM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=32M:3,6,9,12,15,18-HEXAOXAHEXACOSAN-1-OL'>32M</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=32M:3,6,9,12,15,18-HEXAOXAHEXACOSAN-1-OL'>32M</scene>, <scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3iol|3iol]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zgm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zgm OCA], [https://pdbe.org/4zgm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zgm RCSB], [https://www.ebi.ac.uk/pdbsum/4zgm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zgm ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zgm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zgm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zgm RCSB], [http://www.ebi.ac.uk/pdbsum/4zgm PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GLP1R_HUMAN GLP1R_HUMAN]] This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
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[https://www.uniprot.org/uniprot/GLP1R_HUMAN GLP1R_HUMAN] This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4zgm" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Glucagon-like peptide receptor 3D structures|Glucagon-like peptide receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Reedtz-Runge, S]]
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[[Category: Homo sapiens]]
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[[Category: Complex]]
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[[Category: Large Structures]]
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[[Category: Glp-1]]
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[[Category: Reedtz-Runge S]]
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[[Category: Receptor]]
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[[Category: Signaling protein]]
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Current revision

Crystal structure of Semaglutide peptide backbone in complex with the GLP-1 receptor extracellular domain

PDB ID 4zgm

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