4zlr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:00, 10 January 2024) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Structure of the Brat-NHL domain bound to consensus RNA motif==
==Structure of the Brat-NHL domain bound to consensus RNA motif==
-
<StructureSection load='4zlr' size='340' side='right' caption='[[4zlr]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
+
<StructureSection load='4zlr' size='340' side='right'caption='[[4zlr]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4zlr]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZLR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZLR FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4zlr]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZLR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZLR FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zlr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zlr OCA], [http://pdbe.org/4zlr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zlr RCSB], [http://www.ebi.ac.uk/pdbsum/4zlr PDBsum]</span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zlr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zlr OCA], [https://pdbe.org/4zlr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zlr RCSB], [https://www.ebi.ac.uk/pdbsum/4zlr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zlr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/BRAT_DROME BRAT_DROME]] Plays a central role in translation repression of hb mRNA by being recruited by nos and pum to the Nanos Response Element (NRE), a 16 bp sequence in the hb mRNA 3'-UTR. Probably recruited by other proteins to repress translation of other mRNAs in other tissues. Involved in the regulation of ribosomal RNA synthesis and cell growth. Participates in abdominal segmentation and imaginal disk development. Involved in brain tumor suppression, by acting as a growth suppressor in the larval brain.<ref>PMID:11274060</ref> <ref>PMID:11807032</ref>
+
[https://www.uniprot.org/uniprot/BRAT_DROME BRAT_DROME] Plays a central role in translation repression of hb mRNA by being recruited by nos and pum to the Nanos Response Element (NRE), a 16 bp sequence in the hb mRNA 3'-UTR. Probably recruited by other proteins to repress translation of other mRNAs in other tissues. Involved in the regulation of ribosomal RNA synthesis and cell growth. Participates in abdominal segmentation and imaginal disk development. Involved in brain tumor suppression, by acting as a growth suppressor in the larval brain.<ref>PMID:11274060</ref> <ref>PMID:11807032</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 21: Line 23:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Jakob, L]]
+
[[Category: Drosophila melanogaster]]
-
[[Category: Loedige, I]]
+
[[Category: Large Structures]]
-
[[Category: Meister, G]]
+
[[Category: Synthetic construct]]
-
[[Category: Stotz, M]]
+
[[Category: Jakob L]]
-
[[Category: Treiber, N]]
+
[[Category: Loedige I]]
-
[[Category: Treiber, T]]
+
[[Category: Meister G]]
-
[[Category: Beta-propeller]]
+
[[Category: Stotz M]]
-
[[Category: Nhl-domain]]
+
[[Category: Treiber N]]
-
[[Category: Rna binding]]
+
[[Category: Treiber T]]
-
[[Category: Translation]]
+
-
[[Category: Translational repressor]]
+

Current revision

Structure of the Brat-NHL domain bound to consensus RNA motif

PDB ID 4zlr

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4zlr"
Personal tools