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5a23
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==SdsA sulfatase triclinic form== | |
| + | <StructureSection load='5a23' size='340' side='right'caption='[[5a23]], [[Resolution|resolution]] 2.41Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5a23]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A23 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A23 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.41Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a23 OCA], [https://pdbe.org/5a23 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a23 RCSB], [https://www.ebi.ac.uk/pdbsum/5a23 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a23 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/LPAKS_PSEAE LPAKS_PSEAE] Alkylsulfatase that cleaves both short and medium-length alkylsulfates, including the widely used detergent sodium dodecyl sulfate (SDS) (PubMed:16684886). Acts in vitro on primary alkylsulfates such as decyl sulfate, octyl sulfate and hexyl sulfate, but not on sulfated sugars and arylsulfates (PubMed:16684886, PubMed:23061549). The hydrolysis of SDS allows the bacterium to use SDS as a sole carbon or sulfur source (PubMed:16684886). In addition, contributes to the in vivo virulence of P.aeruginosa by playing a central role in the degradation of mucin, a glycoprotein that is the primary component of the mucus overlaying the host epithelial tissues (PubMed:31907968). Plays a role in the degradation of both protein and carbohydrate moieties in mucin via the release of sulfate from mucin, D-galactose 6-sulfate (Gal-6S) and N-acetyl-D-glucosamine 6-sulfate (GlcNAc-6S) (PubMed:31907968).<ref>PMID:16684886</ref> <ref>PMID:23061549</ref> <ref>PMID:31907968</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Sulfatase 3D structures|Sulfatase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Pseudomonas aeruginosa]] |
| - | [[Category: | + | [[Category: De la Mora E]] |
| - | [[Category: Sanchez-Puig | + | [[Category: Flores-Hernandez E]] |
| + | [[Category: Jakoncik J]] | ||
| + | [[Category: Moreno A]] | ||
| + | [[Category: Sanchez-Puig N]] | ||
| + | [[Category: Stojanoff V]] | ||
Current revision
SdsA sulfatase triclinic form
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