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5a4f

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==The mechanism of Hydrogen Activation by NiFe-hydrogenases.==
==The mechanism of Hydrogen Activation by NiFe-hydrogenases.==
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<StructureSection load='5a4f' size='340' side='right' caption='[[5a4f]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
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<StructureSection load='5a4f' size='340' side='right'caption='[[5a4f]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5a4f]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_str._k-12_substr._mc4100 Escherichia coli str. k-12 substr. mc4100]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A4F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A4F FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5a4f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_str._K-12_substr._MC4100 Escherichia coli str. K-12 substr. MC4100]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A4F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A4F FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=F3S:FE3-S4+CLUSTER'>F3S</scene>, <scene name='pdbligand=FCO:CARBONMONOXIDE-(DICYANO)+IRON'>FCO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SF3:FE4-S3+CLUSTER'>SF3</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=F3S:FE3-S4+CLUSTER'>F3S</scene>, <scene name='pdbligand=FCO:CARBONMONOXIDE-(DICYANO)+IRON'>FCO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SF3:FE4-S3+CLUSTER'>SF3</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5a4i|5a4i]], [[5a4m|5a4m]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a4f OCA], [https://pdbe.org/5a4f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a4f RCSB], [https://www.ebi.ac.uk/pdbsum/5a4f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a4f ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrogenase_(acceptor) Hydrogenase (acceptor)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.12.99.6 1.12.99.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a4f OCA], [http://pdbe.org/5a4f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a4f RCSB], [http://www.ebi.ac.uk/pdbsum/5a4f PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MBHL_ECOLI MBHL_ECOLI]] This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD1 is believed to have a role in hydrogen cycling during fermentative growth. [[http://www.uniprot.org/uniprot/MBHS_ECOLI MBHS_ECOLI]] This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD1 is believed to have a role in hydrogen cycling during fermentative growth.
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[https://www.uniprot.org/uniprot/MBHL_ECOLI MBHL_ECOLI] This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD1 is believed to have a role in hydrogen cycling during fermentative growth.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Escherichia coli str. k-12 substr. mc4100]]
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[[Category: Escherichia coli str. K-12 substr. MC4100]]
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[[Category: Armstrong, F A]]
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[[Category: Large Structures]]
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[[Category: Brooke, E J]]
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[[Category: Armstrong FA]]
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[[Category: Carr, S B]]
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[[Category: Brooke EJ]]
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[[Category: Evans, R M]]
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[[Category: Carr SB]]
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[[Category: Nomerotskaia, E]]
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[[Category: Evans RM]]
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[[Category: Phillips, S E.V]]
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[[Category: Nomerotskaia E]]
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[[Category: Sargent, F]]
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[[Category: Phillips SEV]]
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[[Category: Wehlin, S A.M]]
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[[Category: Sargent F]]
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[[Category: Catalysis]]
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[[Category: Wehlin SAM]]
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[[Category: Fes cluster]]
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[[Category: Hydrogen lysis]]
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[[Category: Nife-hydrogenase]]
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[[Category: Oxidoreductase]]
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[[Category: Redox]]
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Current revision

The mechanism of Hydrogen Activation by NiFe-hydrogenases.

PDB ID 5a4f

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