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5a5z

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==Approved Drugs Containing Thiols as Inhibitors of Metallo-beta- lactamases: Strategy To Combat Multidrug-Resistant Bacteria==
==Approved Drugs Containing Thiols as Inhibitors of Metallo-beta- lactamases: Strategy To Combat Multidrug-Resistant Bacteria==
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<StructureSection load='5a5z' size='340' side='right' caption='[[5a5z]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='5a5z' size='340' side='right'caption='[[5a5z]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5a5z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A5Z FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5a5z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A5Z FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=WJZ:TIOPRONIN'>WJZ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WJZ:TIOPRONIN'>WJZ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a5z OCA], [http://pdbe.org/5a5z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a5z RCSB], [http://www.ebi.ac.uk/pdbsum/5a5z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a5z ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a5z OCA], [https://pdbe.org/5a5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a5z RCSB], [https://www.ebi.ac.uk/pdbsum/5a5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a5z ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN]] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.
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[https://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Beta-lactamase|Beta-lactamase]]
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Beta-lactamase]]
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[[Category: Klebsiella pneumoniae]]
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[[Category: Cuesta-Bernal, J]]
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[[Category: Large Structures]]
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[[Category: El-Delik, J]]
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[[Category: Cuesta-Bernal J]]
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[[Category: Frank, D]]
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[[Category: El-Delik J]]
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[[Category: Goettig, S]]
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[[Category: Frank D]]
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[[Category: Klingler, F M]]
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[[Category: Goettig S]]
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[[Category: Koenigs, A]]
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[[Category: Klingler FM]]
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[[Category: Mueller, H F]]
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[[Category: Koenigs A]]
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[[Category: Pogoryelov, D]]
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[[Category: Mueller HF]]
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[[Category: Proschak, E]]
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[[Category: Pogoryelov D]]
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[[Category: Sjuts, H]]
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[[Category: Proschak E]]
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[[Category: Wichelhaus, T A]]
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[[Category: Sjuts H]]
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[[Category: Hydrolase]]
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[[Category: Wichelhaus TA]]
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[[Category: Metallo-beta-lactamase]]
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[[Category: Ndm-1]]
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[[Category: New delhi metallo- beta-lactamase 1]]
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[[Category: Tiopronin]]
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Current revision

Approved Drugs Containing Thiols as Inhibitors of Metallo-beta- lactamases: Strategy To Combat Multidrug-Resistant Bacteria

PDB ID 5a5z

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