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5ae2

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==Ether Lipid-Generating Enzyme AGPS in complex with inhibitor 1e==
==Ether Lipid-Generating Enzyme AGPS in complex with inhibitor 1e==
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<StructureSection load='5ae2' size='340' side='right' caption='[[5ae2]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='5ae2' size='340' side='right'caption='[[5ae2]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ae2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AE2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AE2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ae2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Cavia_porcellus Cavia porcellus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AE2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AE2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FYC:3-(2-FLUOROPHENYL)-2-METHYL-N-((2-OXO-2,3-DIHYDRO-1H-BENZO[D]IMIDAZOL-5-YL)METHYL)ACRYLAMIDE'>FYC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5adz|5adz]], [[5ae1|5ae1]], [[5ae3|5ae3]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FYC:3-(2-FLUOROPHENYL)-2-METHYL-N-((2-OXO-2,3-DIHYDRO-1H-BENZO[D]IMIDAZOL-5-YL)METHYL)ACRYLAMIDE'>FYC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ae2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ae2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5ae2 RCSB], [http://www.ebi.ac.uk/pdbsum/5ae2 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ae2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ae2 OCA], [https://pdbe.org/5ae2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ae2 RCSB], [https://www.ebi.ac.uk/pdbsum/5ae2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ae2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ADAS_CAVPO ADAS_CAVPO]] Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.<ref>PMID:23112191</ref>
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[https://www.uniprot.org/uniprot/ADAS_CAVPO ADAS_CAVPO] Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.<ref>PMID:23112191</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 5ae2" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Aliverti, A]]
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[[Category: Cavia porcellus]]
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[[Category: Benjamin, D I]]
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[[Category: Large Structures]]
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[[Category: Mai, A]]
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[[Category: Aliverti A]]
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[[Category: Marrocco, B]]
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[[Category: Benjamin DI]]
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[[Category: Mattevi, A]]
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[[Category: Mai A]]
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[[Category: Nenci, S]]
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[[Category: Marrocco B]]
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[[Category: Nomura, D K]]
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[[Category: Mattevi A]]
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[[Category: Piano, V]]
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[[Category: Nenci S]]
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[[Category: Valente, S]]
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[[Category: Nomura DK]]
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[[Category: Cancer]]
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[[Category: Piano V]]
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[[Category: Ether phospholipid]]
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[[Category: Valente S]]
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[[Category: Flavin]]
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[[Category: Transferase]]
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Current revision

Ether Lipid-Generating Enzyme AGPS in complex with inhibitor 1e

PDB ID 5ae2

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