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5ahm

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==IMP-bound form of the DeltaCBS mutant of IMPDH from Pseudomonas aeruginosa==
==IMP-bound form of the DeltaCBS mutant of IMPDH from Pseudomonas aeruginosa==
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<StructureSection load='5ahm' size='340' side='right' caption='[[5ahm]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
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<StructureSection load='5ahm' size='340' side='right'caption='[[5ahm]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ahm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AHM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AHM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ahm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AHM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AHM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ahl|5ahl]], [[5ahn|5ahn]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ahm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ahm OCA], [https://pdbe.org/5ahm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ahm RCSB], [https://www.ebi.ac.uk/pdbsum/5ahm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ahm ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ahm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ahm OCA], [http://pdbe.org/5ahm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ahm RCSB], [http://www.ebi.ac.uk/pdbsum/5ahm PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/Q9HXM5_PSEAE Q9HXM5_PSEAE]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).[HAMAP-Rule:MF_01964]
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[https://www.uniprot.org/uniprot/Q9HXM5_PSEAE Q9HXM5_PSEAE] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).[HAMAP-Rule:MF_01964]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5ahm" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5ahm" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Inosine monophosphate dehydrogenase 3D structures|Inosine monophosphate dehydrogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: IMP dehydrogenase]]
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[[Category: Large Structures]]
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[[Category: Alexandre, T]]
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[[Category: Pseudomonas aeruginosa PAO1]]
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[[Category: Gelin, M]]
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[[Category: Alexandre T]]
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[[Category: Haouz, A]]
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[[Category: Gelin M]]
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[[Category: Labesse, G]]
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[[Category: Haouz A]]
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[[Category: Munier-Lehmann, H]]
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[[Category: Labesse G]]
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[[Category: Allosteric regu nucleotide metabolism]]
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[[Category: Munier-Lehmann H]]
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[[Category: Cbs module]]
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[[Category: Deletion mutant]]
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[[Category: Oxidoreductase]]
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Current revision

IMP-bound form of the DeltaCBS mutant of IMPDH from Pseudomonas aeruginosa

PDB ID 5ahm

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