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5bpv
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Zaire ebolavirus VP35 RNA binding domain mutant I278A== | |
| - | + | <StructureSection load='5bpv' size='340' side='right'caption='[[5bpv]], [[Resolution|resolution]] 1.95Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5bpv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Zaire_ebolavirus Zaire ebolavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BPV FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.952Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpv OCA], [https://pdbe.org/5bpv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bpv RCSB], [https://www.ebi.ac.uk/pdbsum/5bpv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bpv ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/VP35_EBOZM VP35_EBOZM] Acsts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR.<ref>PMID:9971816</ref> <ref>PMID:11027311</ref> <ref>PMID:12829834</ref> <ref>PMID:16495261</ref> <ref>PMID:17065211</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Esposito | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Zaire ebolavirus]] |
| - | [[Category: Maccioni | + | [[Category: Alcaro S]] |
| - | [[Category: | + | [[Category: Bianco G]] |
| - | [[Category: | + | [[Category: Cannas V]] |
| + | [[Category: Corona A]] | ||
| + | [[Category: Daino GL]] | ||
| + | [[Category: Distinto S]] | ||
| + | [[Category: Esposito F]] | ||
| + | [[Category: Fadda V]] | ||
| + | [[Category: Maccioni E]] | ||
| + | [[Category: Taylor GL]] | ||
| + | [[Category: Tramontano E]] | ||
| + | [[Category: Zinzula L]] | ||
Current revision
Crystal Structure of Zaire ebolavirus VP35 RNA binding domain mutant I278A
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Categories: Large Structures | Zaire ebolavirus | Alcaro S | Bianco G | Cannas V | Corona A | Daino GL | Distinto S | Esposito F | Fadda V | Maccioni E | Taylor GL | Tramontano E | Zinzula L
