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5ciy

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==Structural basis of the recognition of H3K36me3 by DNMT3B PWWP domain==
==Structural basis of the recognition of H3K36me3 by DNMT3B PWWP domain==
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<StructureSection load='5ciy' size='340' side='right' caption='[[5ciy]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
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<StructureSection load='5ciy' size='340' side='right'caption='[[5ciy]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ciy]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CIY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CIY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ciy]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_haemolyticus Haemophilus haemolyticus] and [https://en.wikipedia.org/wiki/Haemophilus_parahaemolyticus Haemophilus parahaemolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CIY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CIY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.594&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=3DR:1,2-DIDEOXYRIBOFURANOSE-5-PHOSPHATE'>3DR</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3DR:1,2-DIDEOXYRIBOFURANOSE-5-PHOSPHATE'>3DR</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_(cytosine-5-)-methyltransferase DNA (cytosine-5-)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.37 2.1.1.37] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ciy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ciy OCA], [https://pdbe.org/5ciy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ciy RCSB], [https://www.ebi.ac.uk/pdbsum/5ciy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ciy ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ciy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ciy OCA], [http://pdbe.org/5ciy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ciy RCSB], [http://www.ebi.ac.uk/pdbsum/5ciy PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MTH1_HAEPH MTH1_HAEPH]] This methylase recognizes the double-stranded sequence GCGC, causes specific methylation on C-2 on both strands, and protects the DNA from cleavage by the HhaI endonuclease.
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[https://www.uniprot.org/uniprot/MTH1_HAEPH MTH1_HAEPH] This methylase recognizes the double-stranded sequence GCGC, causes specific methylation on C-2 on both strands, and protects the DNA from cleavage by the HhaI endonuclease.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5ciy" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5ciy" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[DNA methyltransferase 3D structures|DNA methyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: MASO, T DAL]]
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[[Category: Haemophilus haemolyticus]]
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[[Category: RONDELET, G]]
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[[Category: Haemophilus parahaemolyticus]]
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[[Category: WILLEMS, L]]
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[[Category: Large Structures]]
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[[Category: WOUTERS, J]]
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[[Category: DAL MASO T]]
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[[Category: C5-methylcytosine]]
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[[Category: Rondelet G]]
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[[Category: Cg-specificity]]
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[[Category: Willems L]]
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[[Category: Cpg sequence]]
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[[Category: Wouters J]]
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[[Category: Nucleotide flipping]]
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[[Category: S-adenosyl-l-homocysteine]]
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[[Category: Transferase-dna complex]]
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Current revision

Structural basis of the recognition of H3K36me3 by DNMT3B PWWP domain

PDB ID 5ciy

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