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5cqv

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'''Unreleased structure'''
 
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The entry 5cqv is ON HOLD until Paper Publication
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==Crystal structure of uncharacterized protein Q8DWV2 from Streptococcus agalactiae==
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<StructureSection load='5cqv' size='340' side='right'caption='[[5cqv]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5cqv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_agalactiae_2603V/R Streptococcus agalactiae 2603V/R]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CQV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CQV FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cqv OCA], [https://pdbe.org/5cqv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cqv RCSB], [https://www.ebi.ac.uk/pdbsum/5cqv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cqv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8DWV2_STRA5 Q8DWV2_STRA5]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Bacteria have developed a variety of mechanisms for surviving harsh environmental conditions, nutrient stress and overpopulation. Paenibacillus dendritiformis produces a lethal protein (Slf) that is able to induce cell death in neighbouring colonies and a phenotypic switch in more distant ones. Slf is derived from the secreted precursor protein, DfsB, after proteolytic processing. Here, we present new crystal structures of DfsB homologues from a variety of bacterial species and a surprising version present in the yeast Saccharomyces cerevisiae. Adopting a four-helix bundle decorated with a further three short helices within intervening loops, DfsB belongs to a non-enzymatic class of the DinB fold. The structure suggests that the biologically active Slf fragment may possess a C-terminal helix rich in basic and aromatic residues that suggest a functional mechanism akin to that for cationic antimicrobial peptides.
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Authors: Taylor, J.D., Hare, S., Matthews, S.J.
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Structures of the DfsB Protein Family Suggest a Cationic, Helical Sibling Lethal Factor Peptide.,Taylor JD, Taylor G, Hare SA, Matthews SJ J Mol Biol. 2016 Jan 21. pii: S0022-2836(16)00032-2. doi:, 10.1016/j.jmb.2016.01.013. PMID:26804569<ref>PMID:26804569</ref>
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Description: Crystal structure of uncharacterized protein Q8DWV2 from Streptococcus agalactiae
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Matthews, S.J]]
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<div class="pdbe-citations 5cqv" style="background-color:#fffaf0;"></div>
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[[Category: Hare, S]]
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== References ==
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[[Category: Taylor, J.D]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Streptococcus agalactiae 2603V/R]]
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[[Category: Hare S]]
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[[Category: Matthews SJ]]
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[[Category: Taylor JD]]

Current revision

Crystal structure of uncharacterized protein Q8DWV2 from Streptococcus agalactiae

PDB ID 5cqv

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