5dfd

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==Crystal structure of BRD2(BD2) W370F mutant with ligand 28 bound==
==Crystal structure of BRD2(BD2) W370F mutant with ligand 28 bound==
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<StructureSection load='5dfd' size='340' side='right' caption='[[5dfd]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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<StructureSection load='5dfd' size='340' side='right'caption='[[5dfd]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5dfd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DFD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DFD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5dfd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DFD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DFD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=59E:METHYL+[(4S)-6-(1H-INDOL-4-YL)-8-METHOXY-1-METHYL-4H-[1,2,4]TRIAZOLO[4,3-A][1,4]BENZODIAZEPIN-4-YL]ACETATE'>59E</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dfd OCA], [http://pdbe.org/5dfd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dfd RCSB], [http://www.ebi.ac.uk/pdbsum/5dfd PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=59E:METHYL+[(4S)-6-(1H-INDOL-4-YL)-8-METHOXY-1-METHYL-4H-[1,2,4]TRIAZOLO[4,3-A][1,4]BENZODIAZEPIN-4-YL]ACETATE'>59E</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dfd OCA], [https://pdbe.org/5dfd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dfd RCSB], [https://www.ebi.ac.uk/pdbsum/5dfd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dfd ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
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[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Bromodomain-containing protein|Bromodomain-containing protein]]
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*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Baud, M]]
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[[Category: Homo sapiens]]
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[[Category: Chirgadze, D Y]]
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[[Category: Large Structures]]
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[[Category: Ciulli, A]]
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[[Category: Baud M]]
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[[Category: Lin-Shiao, E]]
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[[Category: Chirgadze DY]]
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[[Category: Tallant, C]]
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[[Category: Ciulli A]]
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[[Category: Bet bromodomain]]
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[[Category: Lin-Shiao E]]
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[[Category: Molecular probe]]
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[[Category: Tallant C]]
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[[Category: Protein mutation engineering]]
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[[Category: Transcription]]
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[[Category: Transcription factor]]
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Current revision

Crystal structure of BRD2(BD2) W370F mutant with ligand 28 bound

PDB ID 5dfd

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