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5dy7

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==Crystal structure of the human BRPF1 bromodomain in complex with SEED4==
==Crystal structure of the human BRPF1 bromodomain in complex with SEED4==
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<StructureSection load='5dy7' size='340' side='right' caption='[[5dy7]], [[Resolution|resolution]] 1.69&Aring;' scene=''>
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<StructureSection load='5dy7' size='340' side='right'caption='[[5dy7]], [[Resolution|resolution]] 1.69&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5dy7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DY7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DY7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5dy7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DY7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DY7 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5GT:7-(TRIFLUOROMETHYL)-3,4-DIHYDROQUINOXALIN-2(1H)-ONE'>5GT</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.69&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5c7n|5c7n]], [[5c85|5c85]], [[5c87|5c87]], [[5c89|5c89]], [[5d7x|5d7x]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5GT:7-(TRIFLUOROMETHYL)-3,4-DIHYDROQUINOXALIN-2(1H)-ONE'>5GT</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dy7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dy7 OCA], [http://pdbe.org/5dy7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dy7 RCSB], [http://www.ebi.ac.uk/pdbsum/5dy7 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dy7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dy7 OCA], [https://pdbe.org/5dy7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dy7 RCSB], [https://www.ebi.ac.uk/pdbsum/5dy7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dy7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref>
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[https://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5dy7" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5dy7" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Peregrin|Peregrin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Caflisch, A]]
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[[Category: Homo sapiens]]
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[[Category: Zhu, J]]
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[[Category: Large Structures]]
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[[Category: Dna binding protein]]
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[[Category: Caflisch A]]
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[[Category: Inhibitor]]
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[[Category: Zhu J]]
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[[Category: Transcription]]
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Current revision

Crystal structure of the human BRPF1 bromodomain in complex with SEED4

PDB ID 5dy7

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