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7xw9
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of the TRH-bound human TRHR-Gq complex== | |
| - | + | <StructureSection load='7xw9' size='340' side='right'caption='[[7xw9]], [[Resolution|resolution]] 2.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7xw9]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XW9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XW9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.7Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xw9 OCA], [https://pdbe.org/7xw9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xw9 RCSB], [https://www.ebi.ac.uk/pdbsum/7xw9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xw9 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Disease == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/TRFR_HUMAN TRFR_HUMAN] Resistance to thyrotropin-releasing hormone syndrome. The disease is caused by variants affecting the gene represented in this entry. |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/TRFR_HUMAN TRFR_HUMAN] Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.<ref>PMID:26735259</ref> <ref>PMID:9141550</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: Ji | + | <references/> |
| - | [[Category: Shen | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Bos taurus]] |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Rattus norvegicus]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Chen L]] | ||
| + | [[Category: Dong Y]] | ||
| + | [[Category: Guo J]] | ||
| + | [[Category: Ji S]] | ||
| + | [[Category: Mao C]] | ||
| + | [[Category: Qin J]] | ||
| + | [[Category: Shen D]] | ||
| + | [[Category: Shen Q]] | ||
| + | [[Category: Wang W]] | ||
| + | [[Category: Zang S]] | ||
| + | [[Category: Zhang H]] | ||
| + | [[Category: Zhang Y]] | ||
Current revision
Cryo-EM structure of the TRH-bound human TRHR-Gq complex
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Categories: Bos taurus | Homo sapiens | Large Structures | Rattus norvegicus | Synthetic construct | Chen L | Dong Y | Guo J | Ji S | Mao C | Qin J | Shen D | Shen Q | Wang W | Zang S | Zhang H | Zhang Y
